Method for treating symptoms associated with vascular headaches by administering a combination of calcium and vitamin D

• US 5,443,850 A
• Filed: 03/01/1994
• Issued: 08/22/1995
• Est. Priority Date: 09/15/1992
• Status: Expired due to Fees

• Current Assignee: Susan Thys-Jacobs
• Original Assignee: Susan Thys-Jacobs
• Inventors: Thys-Jacobs, Susan
• Primary Examiner(s): Henley, III, Raymond
• Assistant Examiner(s): CRIARES, THEODORE J
• Application Number:
  US08/203,259
• Time in Patent Office: 539 Days
• Field of Search: 514/167, 552/653, 424/687, 424/682
• US Class Current: 424/682
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/59 Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 25/06 Antimigraine agents

Abstract

The present invention is directed to a method for treating symptoms associated with vascular headaches. The method comprises administering to an individual exhibiting symptoms associated with vascular headache symptomatology a therapeutically effective amount of a combination of calcium and vitamin D.

Claims

1. A method for treating a vascular headache comprising administering to an individual having symptoms associated with vascular headache symptomatology an amount of a combination of calcium and vitamin D effective to significantly reduce said symptoms.

2. The method of claim 1 wherein the vitamin D is administered in the form of ergocalciferol (D2), cholecalciferol (D3) or calcidiol.

3. The method of claim 1 wherein the calcium comprises elemental calcium administered in the form of calcium carbonate, calcium citrate, calcium gluconate, calcium lactate, calcium acetate, or calcium stearate.

4. The method of claim 1 wherein the calcium comprises elemental calcium administered in an oral dose in the range of from about 600 to 3000 mg daily.

5. The method of claim 1 wherein the vitamin D comprises vitamin D2 or D3 administered in an oral dose in the range of from about 400 to 4000 IU per day.

6. The method of claim 1 wherein the vitamin D comprises vitamin D2 or D3 administered in an oral dose in the range of from about 50,000 to 200,000 IU weekly.

7. The method of claim 1 wherein the vitamin D comprises vitamin D2 administered as an intramuscular dose of 100,000 to 500,000 IU in an oil base every 2≧

3 months.

8. The method of claim 1 wherein the calcium comprises elemental calcium administered as an oral, sublingual, parenteral or transdermal dose.

9. The method of claim 1 wherein the vitamin D is administered as an oral, sublingual, parenteral or transdermal dose.

10. The method of claim 1 wherein the calcium is administered in an amount of about 2000 mg per day and the vitamin D is administered in an amount of about 1000 IU per day.

11. The method of claim 1 wherein the calcium is administered in an amount of about 1200 mg per day and the vitamin D is administered in an amount of about 1200 IU per day.

12. The method of claim 1 wherein the calcium is administered in an amount of about 2000 mg per day and the vitamin D is administered in an amount of about 4000 IU per day.

13. The method of claim 1 wherein the calcium is administered in an amount of about 600 mg 2 to 3 times daily and the vitamin D is administered in an amount of about 600 IU 2 to 3 times daily.

14. The method of claim 1 wherein the calcium is administered in an amount of about 600 mg 2 to 3 times daily and the vitamin D is administered in an amount of about 1200 IU 2 to 3 times daily.

15. The method of claim 1 wherein the calcium is administered in an amount of about 800 mg 2 to 3 times daily and the vitamin D is administered in an amount of about 400 IU 2 to 3 times daily.

16. The method of claim 1 wherein the calcium and the vitamin D are administered in the form of a tablet, capsule, powder, liquid, candy, cookie, or transdermal patch.

17. The method of claim 1 wherein the vitamin D is administered in an amount effective to elevate the individual'"'"'s 25 hydroxyvitamin D level to a level greater than 30-40 ng/ml.

18. A method for treating vasospasm comprising administering to an individual having symptoms associated with vasospasm an amount of a combination of calcium and vitamin D effective to significantly reduce the symptoms.