Enhancement of transdermal delivery with ultrasound and chemical enhancers
First Claim
1. In a method for enhancing the transdermal flux rate of an active permeant into a selected area of an individual'"'"'s body surface comprising the steps of (a) contacting the selected area with a composition comprising an effective amount of said permeant;
- and (b) enhancing the permeability of the selected area to the permeant by means of applying ultrasound to said selected area for a time and at an intensity and a frequency effective to enhance the transdermal flux rate into the body;
the improvement comprising;
modulating said applied ultrasound by means of a member selected from the group consisting of frequency modulation, amplitude modulation, phase modulation and combinations thereof.
13 Assignments
0 Petitions
Accused Products
Abstract
A method of enhancing the permeability of the skin or mucosa to a biologically active permeant or drug is described utilizing ultrasound or ultrasound plus a chemical enhancer. If desired the ultrasound may be modulated by means of frequency modulation, amplitude modulation, phase modulation and/or combinations thereof. A frequency modulation from high to low develops a local pressure gradient directed into the body, thus permitting permeant to traverse the skin or mucosa. The enhanced delivery is preferably accomplished using a chemical enhancer, applying ultrasound optionally at a modulated frequency, amplitude, phase, or combinations thereof that further induces a local pressure gradient into the body. The method is also useful as a means for application of a tattoo by noninvasively delivering a pigment through the skin surface.
517 Citations
33 Claims
-
1. In a method for enhancing the transdermal flux rate of an active permeant into a selected area of an individual'"'"'s body surface comprising the steps of (a) contacting the selected area with a composition comprising an effective amount of said permeant;
- and (b) enhancing the permeability of the selected area to the permeant by means of applying ultrasound to said selected area for a time and at an intensity and a frequency effective to enhance the transdermal flux rate into the body;
the improvement comprising;
modulating said applied ultrasound by means of a member selected from the group consisting of frequency modulation, amplitude modulation, phase modulation and combinations thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
- and (b) enhancing the permeability of the selected area to the permeant by means of applying ultrasound to said selected area for a time and at an intensity and a frequency effective to enhance the transdermal flux rate into the body;
-
20. A method for applying a tattoo to a selected area of skin on an individual'"'"'s body surface comprising the steps of:
-
(a) contacting the selected area of skin with a pigment; and (b) enhancing the permeability of the selected area to said pigment for a time sufficient to enable the pigment to penetrate through an outer layer of the body surface, wherein said enhancement is accomplished by application to the selected area of a means selected from the group consisting of ultrasound, chemical permeation enhancement, iontophoresis, electroporation, and combinations thereof. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
-
Specification