Method for analyzing a component of a liquid sample
First Claim
1. A method for analyzing a component of a liquid sample, said method comprising the steps of:
- providing a test-strip analyzer including a test-strip, a code substrate, and a valuation device, wherein the test-strip includes reagents, and wherein the component of the liquid sample reacts with the reagents, the reaction between the reagents and the component resulting in a physically detectable change, the code substrate including a binary valuation code comprising bright and dark zones along at least one track and arrayed according to a predetermined symbols code, the valuation device including a test-strip seat to position a test-strip into a measurement position to measure the physically detectable change and to generate a measurement signal, the valuation device also including a code reader to read the valuation code contained on the code substrate, and computation means to compute an analytical result from the measurement signal taking into account the valuation code;
said method further comprising the steps ofinitiating a relative motion between the code substrate and an optical-electrical transducer of said valuation device;
generating a binary signal in said analyzer during said relative motion of said optical transducer scanning at least one track of the valuation code, said binary signal containing information relating to the valuation code;
generating an output voltage from detected brightness values, with a present maximum peak voltage value of the output voltage for each bright zone being ascertained thereby when reading a bright zone, wherein a peak detection is carried out such that the present maximum peak voltage value follows the output voltage when the output voltage is rising above the present maximum peak voltage value and the present maximum peak voltage value is held constant when the output voltage is falling or constant, the present maximum peak voltage value being also held constant during reading a dark zone, until a reset to a first peak voltage value lower than the present maximum peak voltage value is performed; and
a present minimum peak voltage value of the output voltage for each dark zone being ascertained when reading a dark zone, wherein a peak detection is carried out such that the present minimum peak voltage value follows the output voltage when the output voltage is falling below the present minimum peak voltage value and the present minimum peak voltage value is held constant when the output voltage is rising or constant, the present minimum peak voltage value being also held constant during reading a bright zone, until a reset to a second peak voltage value higher than the present minimum peak voltage value is performed;
generating a present first comparison voltage which is less by a predetermined first amount than the present maximum peak voltage value;
generating a present second comparison voltage which is larger by a predetermined second amount than the present minimum peak voltage value;
comparing the output voltage with the present first comparison voltage and moving the binary signal into a first binary state and resetting the present minimum peak voltage value to the second peak voltage value when the present output voltage drops below the present first comparison voltage; and
comparing the output voltage with the present second comparison voltage and moving the binary signal into a second binary state and resetting the present, maximum peak voltage value to the first peak voltage value when the output voltage rises above the present second comparison voltage and inserting a code substrate into the code reader, thereby reading the valuation code contained thereon during the relative motion, inserting a test strip into the test strip seat, measuring the physically detectable change and analyzing therefrom the component of the liquid sample which was contacted to the test strip by the computation means, thereby taking into account the valuation code.
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Abstract
A method and apparatus for analyzing a component of a liquid sample performs the analysis in a number of steps. A test-strip analyzer is provided, which includes a test-strip, a code substrate, and a valuation device. The test-strip includes reagents, and the component of the liquid sample reacts with the reagents. The reaction results in a physically detectable change. The method includes the steps of initiating a relative motion between the code substrate and an optical-electrical transducer of the valuation device, and generating a binary signal in the analyzer. The binary signal is generated as a result of the relative motion, and contains information of the valuation code and the optical transducer during the motion scanning at least one track of the analytical code. An output voltage is generated from detected brightness values, and maximum and minimum peak voltages are ascertained when reading a bright zone and a dark zone, respectively. A first and second comparison voltages are generated, with the first comparison voltage being less by a first amount than a maximum peak voltage value, and the second comparison voltage being larger by a second amount than the minimum peak voltage value. The output voltage of the transducer is compared with the first and second comparison voltages. The minimum peak voltage value is reset to a higher voltage value when the output voltage drops below the first comparison voltage, and the maximum peak voltage value is reset to a lower peak voltage value when the output voltage rises above the second comparison voltage.
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Citations
19 Claims
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1. A method for analyzing a component of a liquid sample, said method comprising the steps of:
providing a test-strip analyzer including a test-strip, a code substrate, and a valuation device, wherein the test-strip includes reagents, and wherein the component of the liquid sample reacts with the reagents, the reaction between the reagents and the component resulting in a physically detectable change, the code substrate including a binary valuation code comprising bright and dark zones along at least one track and arrayed according to a predetermined symbols code, the valuation device including a test-strip seat to position a test-strip into a measurement position to measure the physically detectable change and to generate a measurement signal, the valuation device also including a code reader to read the valuation code contained on the code substrate, and computation means to compute an analytical result from the measurement signal taking into account the valuation code;
said method further comprising the steps ofinitiating a relative motion between the code substrate and an optical-electrical transducer of said valuation device; generating a binary signal in said analyzer during said relative motion of said optical transducer scanning at least one track of the valuation code, said binary signal containing information relating to the valuation code; generating an output voltage from detected brightness values, with a present maximum peak voltage value of the output voltage for each bright zone being ascertained thereby when reading a bright zone, wherein a peak detection is carried out such that the present maximum peak voltage value follows the output voltage when the output voltage is rising above the present maximum peak voltage value and the present maximum peak voltage value is held constant when the output voltage is falling or constant, the present maximum peak voltage value being also held constant during reading a dark zone, until a reset to a first peak voltage value lower than the present maximum peak voltage value is performed; and
a present minimum peak voltage value of the output voltage for each dark zone being ascertained when reading a dark zone, wherein a peak detection is carried out such that the present minimum peak voltage value follows the output voltage when the output voltage is falling below the present minimum peak voltage value and the present minimum peak voltage value is held constant when the output voltage is rising or constant, the present minimum peak voltage value being also held constant during reading a bright zone, until a reset to a second peak voltage value higher than the present minimum peak voltage value is performed;generating a present first comparison voltage which is less by a predetermined first amount than the present maximum peak voltage value; generating a present second comparison voltage which is larger by a predetermined second amount than the present minimum peak voltage value; comparing the output voltage with the present first comparison voltage and moving the binary signal into a first binary state and resetting the present minimum peak voltage value to the second peak voltage value when the present output voltage drops below the present first comparison voltage; and comparing the output voltage with the present second comparison voltage and moving the binary signal into a second binary state and resetting the present, maximum peak voltage value to the first peak voltage value when the output voltage rises above the present second comparison voltage and inserting a code substrate into the code reader, thereby reading the valuation code contained thereon during the relative motion, inserting a test strip into the test strip seat, measuring the physically detectable change and analyzing therefrom the component of the liquid sample which was contacted to the test strip by the computation means, thereby taking into account the valuation code. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A test-strip analyzer for analyzing a component of a liquid sample, said test-strip analyzer comprising:
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a test-strip containing reagents which react with said component of the liquid sample, the reaction between the reagents and the component resulting in a physically detectable change; a code substrate including a binary valuation code having bright and dark zones along at least one track thereof and arrayed according to a predetermined symbols code; a valuation device for detecting the physically detectable change, analyzing the component of the liquid sample of the test-strip and for reading the code substrate, said valuation device including a test-strip seat to position the test-strip into a measurement position to thereby measure the physically detectable change, and to generate a measurement signal, said valuation device comprising a code reader to read the valuation code contained on the code substrate, and computation means to compute an analytical result from the measurement signal; an optical-electrical transducer for generating a binary signal as a result of a relative motion between the code substrate and the transducer; circuit means for providing an output voltage from the optical transducer to a maximum peak voltage rectifier and to a minimum peak voltage rectifier, said circuit means thereby determining the respective maximum peak voltage of the output voltage when reading a bright zone and the respective minimum peak voltage when reading a dark zone, said circuit means providing the peak voltages to a comparison voltage generator thereof, said comparison voltage generator generating first and second comparison voltages from the difference between successive maximum and minimum voltages and providing said first and second comparison voltages to first and second comparators disposed therein, said first and second comparators comparing the first and second comparison voltages with the output voltage, and generating a binary signal as a function of the comparison, wherein the binary signal contains the information to be analyzed, and wherein the first comparison voltage is less by a predetermined first fraction of the difference than the maximum peak voltage and the second comparison voltage is larger by a predetermined second fraction of the difference than the minimum peak voltage, said circuit means providing a first and second reset component to reset the maximum and minimum peak voltages to a present value of the output voltage as a function of the binary signal output from the second and first comparators, respectively. - View Dependent Claims (17, 18, 19)
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Specification