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Compositions and methods for topical administration of pharmaceutically active agents

  • US 5,446,070 A
  • Filed: 08/27/1993
  • Issued: 08/29/1995
  • Est. Priority Date: 02/27/1991
  • Status: Expired due to Term
First Claim
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1. A flexible, finite, bioadhesive composition for topical application comprising:

  • (a) a therapeutically effective amount of at least one pharmaceutically active agent which is in solid form at ambient temperatures and pressures;

    (b) a pharmaceutically acceptable solvent for the pharmaceutically active agent, in an amount from about 5 to about 70 weight percent based on the weight of the whole composition, said solvent including about 5 to about 50 weight percent of a plasticizer;

    (c) in admixture with the pharmaceutically active agent in the solvent, a pharmaceutically acceptable polysaccharide bioadhesive carrier in an amount from about 20 to about 50 weight percent based on the weight of the whole composition;

    wherein the composition is substantially free of water, substantially water insoluble and is a bioadhesive; and

    wherein the pharmaceutically active agent is present in non-crystallized form in the composition.

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