Medicament dispensing device

• US 5,447,150 A
• Filed: 04/22/1993
• Issued: 09/05/1995
• Est. Priority Date: 12/01/1990
• Status: Expired due to Term

• Current Assignee: Norton Healthcare Limited (Teva Pharmaceutical Industries Limited)
• Original Assignee: Norton Healthcare Limited (Teva Pharmaceutical Industries Limited)
• Inventors: Bacon, Raymond
• Primary Examiner(s): Burr, Edgar S.
• Assistant Examiner(s): Lewis, Aaron J.
• Application Number:
  US08/039,302
• Time in Patent Office: 866 Days
• Field of Search: 128/200.14, 128/200.23, 128/204.23, 128/204.26, 128/202.22
• US Class Current: 128/200.14
• CPC Class Codes: A61M 15/009 using medicine packages with incorporated spraying means, e.g. aerosol cans pocket atomiser of the injector type A61M11/08
• CPC Class Codes: A61M 15/0091 mechanically breath-triggered
• CPC Class Codes: A61M 15/0093 without arming or cocking, e.g. acting directly on the delivery valve
• CPC Class Codes: A61M 15/0096 Hindering inhalation before activation of the dispenser
• CPC Class Codes: A61M 2205/183 the sound being generated pneumatically
• CPC Class Codes: A61M 2205/44 making noise when used incorrectly

Abstract

A metered dose inhaler for use with a pressurised aerosol container which is preferably breath-actuated. A preload (80) is applied to the internal aerosol valve by an amount sufficient to result in a dose release, but this is prevented by the application of a pneumatic resisting force (130). The inhaler comprises a release device (110) which, upon actuation, releases the resisting force and allows the preload to actuate the aerosol valve (135). A metered dose of medicament is then released for inhalation by the patient.

Claims

1. A dispensing device for dispensing a medicant in metered doses in a drug delivery system comprising:

a dispensing device body;

a sleeve disposed in said body and capable of receiving a medicant dispenser;

a means for releasing measured dose of medicant comprising a means for applying a preload force to said sleeve, a means for applying a resisting pneumatic force to said sleeve, and a release device capable of freeing the resisting pneumatic force.

2. A device according to claim 1 wherein the drug delivery system comprises a pressurised inhalation aerosol dispensing container having a valve as a delivery means.

4. A dispensing device according to claim 1 or claim 3, further including a receptacle capable of receiving a dispensing container comprising an outer chamber having a mouthpiece and wherein the inner sleeve is included within the outer chamber, the inner sleeve is capable of at least partly enclosing a main body of an aerosol container.

5. A dispensing device according to claim 4 wherein the outer chamber includes one or more inlets to allow air to flow into the mouthpiece.

3. An inhalation actuable dispensing device for use with a pressurised aerosol dispensing container comprising an inner sleeve capable of receiving a dispensing container, a means for applying a preload force to said sleeve capable of actuating an internal valve of an aerosol container to release a metered dose from a container, a means for applying a resisting pneumatic force to the sleeve capable of preventing actuation of an aerosol valve and an inhalation actuated release device capable of releasing the resisting pneumatic force to allow the preload to actuate an internal valve and allow a metered dose to be dispensed.

6. A dispensing device according to claim 3 wherein the inhalation actuated release device is attached to a movable vane, which on inhalation is capable of moving from a rest position to an actuating position.

7. A dispensing device according to claim 6 wherein the vane is biased such that it will move to its actuating position at a predetermined air flow rate, but will not move to said actuating position at a rate therebelow.

8. A dispensing device according to claim 6 wherein the moveable vane is capable of actuating the release device to allow the preload to actuate an aerosol valve.

9. A dispensing device according to claim 3 wherein the means for applying preload is applied by use of a spring which is capable of operating against an aerosol valve.

10. A dispensing device according to claim 3 wherein the pneumatic resisting force comprises a volume of air held at a positive pressure greater than atmospheric.

11. A dispensing device according to claim 10 wherein the preload comprises a lever pivoted in a recess in the dispensing device, the lever being connected via a plug to a spring, the spring being capable of acting on an aerosol container.

12. A dispensing device according to claim 10 wherein the positive pressure is created by cooperation of an aerosol container, the inner sleeve and a cross member to form a piston.

13. A dispensing device according to claim 3 wherein the pneumatic resisting force comprises a volume of air held at a negative pressure below atmospheric.

14. A dispensing device according to claim 13 wherein the negative pressure is created inside an expandable air-tight volume selected from a bellows, piston, cylinder or a diaphragm that is connected to the sleeve.

15. A dispensing device according to claim 13 wherein the preload comprises a spring acting on the inner sleeve and said spring being compressed by a lever acting on the inner sleeve.

16. A dispensing device according to claim 15 wherein said lever urges against a cam formed upon a rotable cover, such that opening of said cover causes the lever to drop and to release energy stored in the spring to act upon the inner sleeve which is capable of acting upon an aerosol container.

17. A dispensing device according to claim 3 which further comprises a sonic device which will sound a signal when a volume of air passing across the sonic device provides the inhaler with an inspiration rate greater than a pre-set rate.

18. A dispensing device according to claim 3 wherein the release device comprises a valve port, normally covered by a valve flap, which is capable of being opened on actuation of the device.

19. A dispensing device for use with a drug delivery system comprising an inner sleeve capable of receiving a dispensing container, a releasing means for releasing a measured dose, preload means for applying a preload force to the sleeve and capable of actuating the releasing means, resisting means for applying a resisting pneumatic force to the sleeve capable of preventing actuation of the releasing means by the preload means, and preload release means for freeing the resisting pneumatic force to allow the preload to actuate the releasing means.

20. A dispensing device for use with a drug delivery system comprising:

a drug delivery system comprising a dispensing container capable of dispensing a metered dose;

a means for releasing a metered dose;

a sleeve capable of receiving said dispensing container;

wherein said releasing means comprises a means for applying a preload force to said sleeve and capable of actuating said container in said system, a means for applying a resisting pneumatic force to said sleeve capable of preventing actuation of said container, and a release device capable of freeing said resisting pneumatic force to actuate said delivery system and dispense said metered dose.

21. A dispensing device for use with an aerosol medicant container for dispensing a medicant in metered doses comprising:

a main body with a first and second end;

a sleeve comprising sides and a base;

a diaphragm comprising a valve port operationally connected to said second end of said main body and said base of said sleeve;

a spring operationally positioned in said second end of said main body so as to apply a preload force to said sleeve; and

a vane operationally attached to said diaphragm wherein said vane has first and second positions, wherein when said vane is in said first position said vane seals said valve port and when said vane is in said second position said valve port is unsealed.

22. A dispensing device as claimed in claim 21, further comprising:

air inlets disposed in said second end of said main body.

23. A dispensing device as claimed in claim 21, further comprising:

a mouthpiece integrally formed in said first end of said main body.

24. A dispensing device as claimed in claim 23, further comprising:

a dust cap pivotally attached to said first end of said main body capable of covering said mouthpiece wherein said dust cap comprises a cam; and

a cam follower disposed in said main body and operationally connected between said cam and said sleeve.