Optical imaging for specimens having dispersive properties

• US 5,447,159 A
• Filed: 02/03/1993
• Issued: 09/05/1995
• Est. Priority Date: 02/03/1993
• Status: Expired due to Fees

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Schultz, Kenneth I.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): Casler, Brian L.
• Application Number:
  US08/012,877
• Time in Patent Office: 944 Days
• Field of Search: 128/664, 128/665, 128/633, 356/301, 356/349, 356/351, 356/432, 250/358.1
• US Class Current: 600/477
• CPC Class Codes: A61B 5/0091 for mammography
• CPC Class Codes: A61B 5/4312 Breast evaluation or disorder diagnosis A61B5/0091 takes precedence
• CPC Class Codes: G01N 21/41 Refractivity; Phase-affecting properties, e.g. optical path length G01N21/21 takes precedence
• CPC Class Codes: G01N 21/59 Transmissivity G01N21/25 takes precedence

Abstract

A system for optically imaging a specimen is provided, which system amplitude modulates an optical signal with a longer wavelength signal, and in particular a signal having a wavelength which is much longer than any dispersive phase shift in the sample. The modulated optical signal is passed through the specimen. Scattered radiation in the optical output from the sample is filtered out and the resulting optical signal is detected and processed to obtain amplitude/absorption and phase/dispersion information, which information may be used in imaging. Optical signals at different frequencies may be passed through the same sample of the specimen to obtain additional information.

Claims

1. A system for performing optical imaging measurements on a specimen having dispersive properties resulting in phase changes in optical signals applied thereto, the system comprising:

means for generating a coherent, amplitude modulated optical signal having a selected initial amplitude and phase, the amplitude modulation being at a wavelength which is much longer than said phase changes;

means for passing said signal through the specimen to obtain an optical output signal, which output signal has a scatter component;

means for filtering said optical output signal to selectively eliminate said scatter component;

a detector positioned to receive the output from the means for filtering and to generate an electrical output in response thereto;

means for stripping the amplitude modulation from the detector output; and

means for comparing the phase of an amplitude modulation output from the means for stripping with the corresponding selected initial phase to obtain imaging data for said specimen.

2. A system as claimed in claim 1 wherein said means for comparing compares both the amplitude and phase of said amplitude modulation output with said selected initial amplitude and phase.

3. A system as claimed in claim 2 wherein said means for passing passes said signal through a plurality of points of said specimen;

and

wherein said means for comparing includes means for separately storing phase imaging data and amplitude imaging data obtained from said plurality of points.

4. A system as claimed in claim 2 including means for detecting said selected initial amplitude and for generating an electrical reference amplitude in response thereto, and means for applying said electrical reference amplitude signal to said means for comparing.

5. A system as claimed in claim 1 wherein said means for passing passes said signal through a plurality of points of said specimen;

and

wherein said means for comparing includes means for obtaining imaging data for each of said plurality of points.

6. A system as claimed in claim 5 wherein said means for passing includes means for successively passing said signal through each of said plurality of points.

7. A system as claimed in claim 5 including a plurality of said means for generating, and wherein said means for passing includes means for passing the signal from each of the means for generating through a different one of said plurality of points, and wherein there is a separate detector for each of said means for generating.

8. A system as claimed in claim 7 wherein said means for passing includes means for periodically providing relative movement between said means for generating and said specimen to cause said signals to pass through additional ones of said plurality of points.

9. A system as claimed in claim 1 wherein said optical signal is a laser output signal in the visible red frequency range.

10. A system as claimed in claim 1 wherein said amplitude modulation is at a frequency in the 1 GHz to 100 GHz range.

11. A system as claimed in claim 10 wherein said amplitude modulation is at a frequency in the 1 GHz to 10 GHz range.

12. A system as claimed in claim 1 wherein said means for filtering is a spatial filter which substantially eliminates said scatter components.

13. A system as claimed in claim 1 wherein said means for filtering is a heterodyne detector which substantially eliminates said scatter component.

14. A system as claimed in claim 1 wherein said means for stripping is an envelope or square-law detector.

15. A system as claimed in claim 1 wherein said means for generating includes means for generating a modulating signal, and including means for applying the phase of said modulating signal to said means for comparing.

16. A system as claimed in claim 1 wherein said means for generating includes means for generating optical signals at two different frequencies, said means for passing being operative to pass both signals through a given sample of the specimen.

17. A system as claimed in claim 16 wherein said means for passing passes said signals at different frequencies successively through said given sample.

18. A system as claimed in claim 16 wherein said means for passing passes said signals at different frequencies through said given sample simultaneously, and including means for distinguishing said signals in the optical signal output from said specimen.

19. A system as claimed in claim 18 wherein said means for distinguishing includes means for optically polarizing each of the different frequency signals in a different direction, and means for optical polarization filtering the signal output from the specimen.

20. A system as claimed in claim 18 wherein said means for distinguishing includes means for optically modulating each of the different frequency signals at a different frequency, and means for electrically frequency filtering the detector output.