Real time stabilizing system for pulsating activity

• US 5,447,520 A
• Filed: 03/29/1994
• Issued: 09/05/1995
• Est. Priority Date: 08/19/1992
• Status: Expired due to Term

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Ditto, William L., Weiss, James N., Garfinkel, Alan, Spano, Mark L.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US08/219,567
• Time in Patent Office: 525 Days
• Field of Search: 128/702, 128/703, 128/704, 128/705, 607/4, 607/5
• US Class Current: 607/5
• CPC Class Codes: A61N 1/3621 for treating or preventing abnormally high heart rate
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371
• CPC Class Codes: Y10S 128/925 Neural network

Abstract

Electrical stimuli delivered to cardiac tissue at times determined from a chaos stabilizing algorithm, converts arrhythmia activity to periodic beating by an interbeat interval shortening action, utilizing real time calculation based on a system parameter experimentally determined from intervention by the electrical stimuli.

Claims

1. In a method of treating pulsating behavioral activity by monitoring said activity to obtain data from which a chaos system is detected and intervening to effect a shift in status of the chaos system from movements of system state points along an unstable manifold, including the steps of:

performing real time calculation during said monitoring to determine changes in the status of the chaos system from the data obtained by said monitoring; and

deriving from said real time calculation a waiting time for delaying said intervening in accordance with a chaos behavior controlling algorithm;

said delayed intervening including injecting stimulus pulses causing said shift in the status of the chaos system.

2. The method of claim 1 wherein said stimulus pulses are applied by said injecting thereof into living animal tissue within which the monitoring of the behavioral activity is effected.

3. A method of treating pulsating behavioral activity by intervention during an interval of time having a learning phase of predetermined duration, comprising the steps of:

monitoring said activity during the learning phase to obtain data characterizing a chaotic regime;

performing real time calculation to detect status changes in said chaotic regime during said learning phase;

determining from said real time calculation a waiting period; and

instituting said intervention upon termination of the waiting period following the learning phase.

4. A method of controlling pulsating activity of living tissue having spontaneous beats including the steps of:

sensing the spontaneous beats by monitoring variations of said pulsating activity from which establishment of a chaotic regime is detected;

generating a stimulus pulse;

experimentally determining a parameter of said pulsating activity;

performing a real time calculation based on said parameter to determine a waiting period following the sensing of one of said spontaneous beats; and

injecting the stimulus pulse into the living tissue upon completion of said waiting period.

5. The method of claim 4, wherein said step of performing the real time calculation is effected in accordance with a chaos behavior controlling algorithm.

6. The method of claim 4 wherein said step of performing the real time calculation is effected in accordance with a chaos behavior controlling algorithm involving said parameter.