Contrast media

• US 5,447,711 A
• Filed: 03/14/1994
• Issued: 09/05/1995
• Est. Priority Date: 09/04/1989
• Status: Expired due to Term

• Current Assignee: GE Healthcare As (GE Healthcare Technologies, Inc.)
• Original Assignee: Nycomed A/S (Takeda Pharmaceutical Company Limited)
• Inventors: Almen, Torsten, Oksendal, Audun N., Baath, Lars
• Primary Examiner(s): Hollinden, Gary E.
• Assistant Examiner(s): RAND, SCOTT
• Application Number:
  US08/213,454
• Time in Patent Office: 540 Days
• Field of Search: 424/5
• US Class Current: 424/9.452
• CPC Class Codes: A61K 49/0433 containing an organic halogenated X-ray contrast-enhancing agent

Abstract

The decrease in cardiac contractile force which occurs in angiography using contrast media may be reduced without increasing the incidence of ventricular fibrillations by oxygenating the contrast media.

Claims

1. A physiologically tolerable composition consisting essentially of an oxygenated aqueous solution of an iodinated X-ray contrast agent, said solution having an oxygen tension of at least 60 kPa, wherein if said contrast agent is an ionic compound, it has an iodine ratio of at least 3 and wherein said contrast agent is other than metrizamide.

2. A composition as claimed in claim 1 containing a non-ionic X-ray contrast agent.

3. A composition as claimed in claim 1 containing a contrast agent selected from iohexol, ioversol, iopamidol, iotrolan, ioxaglate and iodixanol.

4. A composition as claimed in claim 1 having a pH in the range 6.6 to 7.5.

5. A composition as claimed in claim 1 having a sodium ion concentration of 20 to 60 mM.

6. A method of X-ray imaging a human or non-human animal body, which method comprises introducing by bolus iniection an oxygenated contrast composition as claimed in claim 1 into said body and generating an X-ray image of at least part of said body containing said contrast agent.

7. A method of X-ray imaging a human or non-human animal body, which method comprises introducing by bolus injection an oxygenated contrast medium composition as claimed in claim 2 into said body and generating an X-ray image of at least part of said body containing said contrast agent.

8. A method of X-ray imaging a human or non-human animal body, which method comprises introducing by bolus injection an oxygenated contrast medium composition as claimed in claim 3 into said body and generating an X-ray image of at least part of said body containing said contrast agent.

9. A method of X-ray imaging a human or non-human animal body, which method comprises-introducing by bolus injection an oxygenated contrast medium composition as claimed in claim 4 into said body and generating an X-ray image of at least part of said body containing said contrast agent.

10. A method of X-ray imaging a human or non-human animal body, which method comprises introducing by bolus injection an oxygenated contrast medium composition as claimed in claim 5 into said body and generating an X-ray image of at least part of said body containing said contrast agent.