Pharmaceutical composition for immunoenhancement therapy

• US 5,449,522 A
• Filed: 08/24/1993
• Issued: 09/12/1995
• Est. Priority Date: 08/24/1993
• Status: Expired due to Term

• Current Assignee: Albert Fay Hill
• Original Assignee: Hill Medical Corporation
• Inventors: Hill, Albert F.
• Primary Examiner(s): Krass, Frederick
• Assistant Examiner(s): Hulina, Amy
• Application Number:
  US08/111,288
• Time in Patent Office: 749 Days
• Field of Search: 514/885, 514/4, 514/23, 514/397, 514/, 424/679, 424/717, 424/722, 424/400, 424/568
• US Class Current: 424/722
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 31/415 1,2-Diazoles
• CPC Class Codes: A61K 31/7004 Monosaccharides having only carbon, hydrogen and oxygen atoms
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 38/28 Insulins
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/04 Immunostimulants
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 5/12 for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

This invention provides an immunoenhancement or immunepotentiation therapy comprising administration of potassium, insulin, glucose and, optionally, thyroid, a cholinergic agent and bicarbonate. Therapeutic compositions comprising the above components in appropriate dosages are also provided.

Claims

1. A method for increasing the intracellular potassium content of lymphocytes of a mammal comprising administering to said mammal glucose in the amount of about 4 g-20 g/kg/day, insulin in an amount effective to maintain blood pre-meal and bedtime glucose at about 80-140 mg/dL, potassium in an amount effective to maintain blood levels at least about 5.0 mEq/L, and thyroid in an amount effective to elevate T₄ levels to mild hyperthyroidism, whereby intracellular potassium content of lymphocytes is increased.

5. The method of claim 1 wherein said insulin, glucose and potassium are administered for at least about five days.

2. A method for increasing the intracellular potassium content of lymphocytes of a mammal comprising administering to said mammal glucose in the amount of about 4 g-20 g/kg/day, insulin in an amount effective to maintain blood pre-meal and bedtime glucose at about 80-140 mg/dL, potassium in an amount effective to maintain blood levels at least about 5.0 mEq/L, and bicarbonate in an amount of at least about 1.0 mEq/kg per day, whereby intracellular potassium content of lymphocytes is increased.

3. A method for increasing the intracellular potassium content of lymphocytes of a mammal comprising administering to said mammal glucose in the amount of about 4 g-20 g/kg/day, insulin in an amount effective to maintain blood pre-meal and bedtime glucose at about 80-140 mg/dL, potassium in an amount effective to maintain blood levels at least about 5.0 mEq/L, and a cholinergic agent in an amount of at least about 105 μ

g per day, whereby intracellular potassium content of lymphocytes is increased.

4. The method of claim 3 in which said cholinergic agent is pilocarpine.

6. A method for increasing the intracellular potassium content of lymphocytes of a mammal comprising administering to said mammal glucose in the amount of about 4 g-20 g/kg/day, insulin in an amount effective to maintain blood pre-meal and bedtime glucose at about 80-140 mg/dL, potassium in an amount effective to maintain blood levels at least about 5.0 mEq/L, wherein one unit of insulin per three grams of glucose is administered, whereby intracellular potassium content of lymphocytes is increased.

7. A method for increasing the intracellular potassium content of lymphocytes of a mammal comprising administering to said mammal glucose in the amount of about 4 g-20 g/kg/day, insulin in an amount effective to maintain blood pre-meal and bedtime glucose at about 80-140 mg/dL, and potassium chloride or potassium acetate in an amount effective to maintain blood levels at least about 5.0 mEq/L, whereby intracellular potassium content of lymphocytes is increased.