High spatial resolution area array detection readhead with a reduced sample detection area and method for using the same

• US 5,449,898 A
• Filed: 06/30/1994
• Issued: 09/12/1995
• Est. Priority Date: 06/30/1994
• Status: Expired due to Term

• Current Assignee: Siemens Healthcare Diagnostics Incorporated (Siemens AG)
• Original Assignee: Miles, Inc. (Bayer AG)
• Inventors: Dosmann, Andrew J.
• Primary Examiner(s): Nelms, David C.
• Assistant Examiner(s): LE, QUE TAN
• Application Number:
  US08/273,263
• Time in Patent Office: 439 Days
• Field of Search: 250/208.1, 250/234, 250/235, 250/236, 359/211, 359/669, 348/202
• US Class Current: 250/208.1
• CPC Class Codes: G01N 21/5911 of the scanning type scanning per se G02B
• CPC Class Codes: G02B 26/0891 forming an optical wedge

Abstract

The high spatial resolution area array detection readhead and method for using the same involve modifying an existing area array detection readhead to provide improved spatial resolution within the sample detection area. One modification involves reducing the field of view of the area array detection readhead. The reduction in the field of view increases pixel spatial resolution because the same number of pixels in the area array detector cover a smaller area. This reduction can be achieved by changing the magnification of the lens of the area array detection readhead or by moving the sample detection area closer to the area array detection readhead. The next modification involves properly aligning the reduced field of view within the sample detection area to take advantage of the improved pixel resolution. Preferably, by rotating the typical area array detection readhead 90 degrees with respect to the sample detection area, the length of the reduced field of view aligns with the width of the sample detection area. Finally, an optical wedge is positioned between the area array detection readhead and the sample detection area. The optical wedge is designed to shift the reduced field of view a predetermined number, X, of degrees from normal along the length of the sample detection area to cover a first field of the sample detection area. By inverting the optical wedge or introducing another optical wedge, the field of view is shifted -X degrees from normal and fills the remaining field of the sample detection area. As such, the sample detection area is divided into two fields that cover the entire sample detection area. Accordingly, by switching the optical wedge between the two wedge positions, the improved area array detection readhead shifts the reduced field of view + and -X degrees to image the entire sample detection area at the higher spatial resolution.

Claims

1. An improved area array detection readhead for examining test samples on a sample detection area, comprising:

an area array detector imaging a reduced field of said sample detection area;

an optical wedge positioned between said area array detector and said sample detection area to shift said reduced field on said sample detection area; and

a switching mechanism for changing the position of said optical wedge relative to said area array detector and said sample detection area.

2. The improved area array detection readhead of claim 1 wherein said optical wedge being mounted within a wedge housing, said switching mechanism engaging said wedge housing.

3. The improved area array detection readhead of claim 2 wherein said switching mechanism including a motor engaging said wedge housing.

4. The improved area array detection readhead of claim 1 wherein said area array detector imaging said field through a lens positioned between said optical wedge and said area array detector.

5. The improved area array detection readhead of claim 1 wherein said area array detector utilizing CCD technology.

6. The improved area array detection readhead of claim 1 wherein said area array detector utilizing CID technology.

7. The improved area array detection readhead of claim 1 wherein said area array detector utilizing transistor array technology.

8. The improved area array detection readhead of claim 1 wherein said area array detector positioned such that a length of said reduced field of view aligning with said width of said sample detection area.

9. The improved area array detection readhead of claim 1 wherein said area array detector having an area array with a length and width proportional to about 4×

3 and said sample detection having a length and width proportional to said length and width of said area array, said area array detector being positioned such that said length of said area array aligns with said width of said sample detection array and said field being reduced to slightly over half of said sample detection area.

10. An improved area array detection readhead for examining test samples on a sample detection area, comprising:

an area array detector imaging a reduced field of said sample detection area;

a field shifter positioned between said area array detector and said sample detection area to shift said field on said sample detection area, said field shifter including a first optical wedge and a second optical wedge; and

a switching;

mechanism engaging said field shifter to change the positioning of said first and second optical wedges relative to said area array detector and said sample detection area.

11. The improved area array detection readhead of claim 10 wherein said first and second optical wedges being mounted within a wedge housing, said switching mechanism engaging said wedge housing.

12. The improved area array detection readhead of claim 11 wherein said switching mechanism including a motor engaging said wedge housing.

13. The improved area array detection readhead of claim 11 wherein said switching mechanism including a spring-loaded solenoid engaging said wedge housing.

14. The improved area array detection readhead of claim 10 wherein said area array detector imaging said field through a lens positioned between said optical wedge and said area array detector.

15. The improved area array detection readhead of claim 11 wherein said area array detector utilizing CCD technology.

16. The improved area array detection readhead of claim 10 wherein said area array detector utilizing CID technology.

17. The improved area array detection readhead of claim 10 wherein said area array detector utilizing transistor array technology.

18. The improved area array detection readhead of claim 10 wherein said first optical wedge positioned symeterically opposite said second optical wedge.

19. The improved area array detection readhead of claim 10 wherein said area array detector positioned such that a length of said reduced field of view aligning with said width of said sample detection area.

20. The improved area array detection readhead of claim 19 wherein said area array detector having an area array with a length and width proportional to about 4×

3 and said sample detection having a length and width proportional to said length and width of said area array, said area array detector being positioned such that said length of said area array aligns with said width of said sample detection array and said field being reduced to slightly over half of said sample detection area.

21. An method of improving the spatial resolution of an area array detection readhead for imaging a sample detection area to analyze test samples on said sample detection area, said method comprising the steps of:

reducing said field of view of said area array detector within said sample detection area to improve the spatial resolution of said area array detector;

aligning said field of view within said sample detection area;

shifting said field of view within said sample detection area to cover a first field of said sample detection area; and

shifting said field of view within said sample detection area to cover a second field of said sample detection area.

22. The method of claim 21 wherein said first and second portions cover all of said sample detection area.

23. The method of claim 21 wherein said first step of shifting comprises the step of positioning an optical wedge between said area array detector and said sample detection area.

24. The method of claim 23 wherein said second step of shifting comprises the step of changing the position of said optical wedge relative to said area array detector and said sample detection area.

25. The method of claim 21 wherein said step of reducing comprises moving said sample detection area closer to said area array detector to reduce said field to slightly over half of said sample detection area.

26. The method of claim 21 wherein said step of reducing comprises employing a lens with the desired magnification for said area array detector to reduce said field to slightly over half of said sample detection area.

27. The method of claim 24 or 25 wherein sad step of aligning includes rotating said area array detector such that a length of said field of view aligning with said width of said sample detection area.