Method for correcting the drift offset of a transducer

• US 5,450,336 A
• Filed: 01/29/1993
• Issued: 09/12/1995
• Est. Priority Date: 03/05/1991
• Status: Expired due to Term

• Current Assignee: Aradigm Corporation
• Original Assignee: Aradigm Corporation
• Inventors: Rubsamen, Reid M., Johansson, Eric T.
• Primary Examiner(s): Cosimano, Edward R.
• Application Number:
  US08/010,783
• Time in Patent Office: 956 Days
• Field of Search: 341/120, 364/571.01, 364/571.08
• US Class Current: 702/104
• CPC Class Codes: A61J 7/0418 with electronic history memory
• CPC Class Codes: A61M 15/00 Inhalators drug delivery in endotracheal tubes A61M16/04
• CPC Class Codes: A61M 15/0021 Mouthpieces therefor
• CPC Class Codes: A61M 15/0066 with means for varying the dose size
• CPC Class Codes: A61M 15/008 Electronic counters
• CPC Class Codes: A61M 15/009 using medicine packages with incorporated spraying means, e.g. aerosol cans pocket atomiser of the injector type A61M11/08
• CPC Class Codes: A61M 15/0091 mechanically breath-triggered
• CPC Class Codes: A61M 16/202 electrically actuated
• CPC Class Codes: A61M 2016/0021 with a proportional output signal, e.g. from a thermistor
• CPC Class Codes: A61M 2016/0036 in the breathing tube and used in both inspiratory and expiratory phase
• CPC Class Codes: A61M 2016/0039 in the inspiratory circuit
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/60 with identification means
• CPC Class Codes: A61M 2205/6018 providing set-up signals for the apparatus configuration
• CPC Class Codes: A61M 2205/6027 Electric-conductive bridges closing detection circuits, with or without identifying elements, e.g. resistances, zener-diodes
• CPC Class Codes: A61M 2205/6036 characterised by physical shape, e.g. array of activating switches
• CPC Class Codes: A61M 2205/6045 having complementary physical shapes for indexing or registration purposes
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: A61M 2205/8212 with means or measures taken for minimising energy consumption
• CPC Class Codes: B01F 23/2132 using nozzles
• CPC Class Codes: B01F 35/712 : for feeding fluids
• CPC Class Codes: B01F 35/7179 : using sprayers, nozzles or jets
• CPC Class Codes: B01F 35/71805 : using valves, gates, orifices or openings
• CPC Class Codes: B01F 35/7547 : using valves, gates, orifices or openings
• CPC Class Codes: F16H 35/00 : Gearings or mechanisms with other special functional features
• CPC Class Codes: G01F 1/363 : with electrical or electro-mechanical indication G01F1/37 and G01F1/38 take precedence
• CPC Class Codes: G01F 1/40 : Details of construction of the flow constriction devices
• CPC Class Codes: G01F 1/44 : Venturi tubes
• CPC Class Codes: G01F 1/50 : Correcting or compensating means
• CPC Class Codes: G01F 13/006 : measuring volume in function of time
• CPC Class Codes: G01F 15/002 : for gases
• CPC Class Codes: G01F 25/10 : of flowmeters
• CPC Class Codes: G01F 7/005 : by measuring pressure or differential pressure, created by the use of flow constriction

Abstract

A method for correcting the drift offset of a transducer is disclosed which method is used in connection with a portable, battery-powered, hand-held system for releasing a controlled dose of aerosol medication for inhalation by a patient. The device includes a durable body and a medication cassette inserted in the durable body. The body includes a flow sensor having an asymmetrical orifice that is calibrated, independent of the cassette, to convert the sensed pressure due to flow into a flow rate. The orifice is separately calibrated for an inhalation flow rate range and an exhalation flow rate range over a selected number of known flow rates. The sensed pressure value is corrected for transducer offset drift and converted to a flow rate using the calibration data and piecewise linear interpolation.

Claims

1. A method for correcting the drift offset of a transducer having an analog output signal corresponding to the sensed pressure of a flow in either direction through a flow path, comprising:

(a) providing an analog to digital converter having a defined range of digital counts and identifying a base digital count value of the digital range corresponding to the base zero flow in either direction;

(b) converting the transducer output signal to a digital value at a given sampling rate;

(c) identifying a zero-flow condition through the flow path when the converted transducer voltage signal does not vary more than a selected number of digital counts over a first period of time;

(d) determining a count offset value based on the difference between the identified base digital count value and the digital count output of the analog to digital converter during an identified zero-flow condition;

(e) adjusting the output of the analog to digital converter following the identified zero flow condition by the determined offset value;

(f) maintaining a buffer containing a selected number of digital values acquired last in time;

(g) adding to the buffer each digital value converted from a sampled voltage signal and subtracting from the buffer the oldest digital value for each new value added;

(h) determining the difference between the maximum and minimum values in the buffer; and

(i) determining that a zero-flow condition exists when the determined difference is less than a second selected number of digital counts.

2. The method of claim 1 wherein step (a) further comprises providing an analog to digital converter with a digital count range on the order of 65,536 counts, and step (c) further comprises determining that the digital value does not change by more than +/- 2 digital counts during a period on the order of one-third of a second.

3. The method of claim 1 further comprising deriving a flow rate from the adjusted digital value.

4. The method of claim 1 wherein the second selected number of digital counts is on the order of four.

5. The method of claim 1 wherein step (a) further comprises providing an analog to digital converter with a digital count range on the order of 65,536 counts, and step (c) further comprises selecting the number of digital values in the buffer to be on the order of 25 values and determining that a zero-flow condition exists when the determined difference is less than four digital counts.

6. The method of claim 1 wherein step (d) further comprises:

determining the mean value of the selected number of digital values in the buffer; and

determining the offset value as the difference between the identified base digital count and the determined mean value.

7. The method of claim 6 wherein step (a) further comprises providing an analog to digital converter with a digital count range on the order of 65,536 counts, and step (c) further comprises selecting the number of digital values in the buffer to be on the order of 25 values and determining that a zero-flow condition exists when the determined difference is less than four digital counts.

8. Apparatus for correcting the drift offset of a transducer having an analog output signal corresponding to the sensed pressure of a flow in either direction through a flow path, comprising:

an analog to digital converter having a defined range of digital counts and a digital value in the digital range corresponding to the base zero flow in either direction;

means for controlling the analog to digital converter to convert the transducer output signal to digital value at a given sampling rate;

means for identifying a zero-flow condition through the flow path when the digital values do not vary more than a selected number of digital counts over a first period of time;

first means for determining an offset value based on the difference between the identified base digital count and the digital value output of the analog to digital converter during a zero-flow condition;

means for adjusting the output of the analog to digital converter by the determined offset value;

a buffer for storing a selected number of digital values corresponding to samples of the transducer output taken over the selected time interval;

means for adding a newly acquired digital value to the buffer and subtracting the oldest acquired digital value from the buffer; and

first means for processing the buffer contents to identify a zero-flow condition through the flow path in response to the digital values stored in the buffer not varying more than a selected number of digital counts.

9. The apparatus of claim 8 wherein the analog to digital converter has a digital count range on the order of 65,536 counts, and the identifying means determines that the digital value does not change by more than +/- 2 digital counts during a period on the order of one-third of a second.

10. The apparatus of claim 8 wherein the first processing means further comprises a second means for determining that a zero-flow condition exists when the difference between the maximum and minimum values in the buffer is less than the selected number of digital counts.

11. The apparatus of claim 10 wherein the analog to digital converter has a digital count range on the order of 65,536 counts, the selected number of digital values in the buffer is on the order of 25, and the second determining means determines that a zero-flow condition exists when the determined difference is less than four digital counts.

12. The apparatus of claim 8 wherein the first determining means further comprises second means for processing the buffer contents to determine a mean value of the selected number of digital values in the buffer and determines the offset value as the difference between the identified base digital count and the determined mean value.

13. The apparatus of claim 12 wherein the analog to digital converter has a digital count range on the order of 65,536 counts, and the selected number of digital values in the buffer is on the order of 25, and the first processing means determines that a zero-flow condition exists when the determined difference is less than four digital counts.