Anti-infective and antithrombogenic medical articles and method for their preparation
First Claim
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1. A method for preparing a medical article comprising:
- a) preparing a blend of an anti-infective agent comprising chlorhexide, with pellets of a base polymer having a water absorption of at least 0.6% by weight;
b) heating said blend to a temperature from about 160°
C. to about 250°
C. and for a sufficient time to form a homogenous melt of said polymer having said anti-infective agent uniformly distributed therein; and
c) extruding said melt through a die to form a medical article having said anti-infective agent bulk distributed throughout said polymer.
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Abstract
An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine permeated into the surface or it may be an antibiotic, antithrombogenic agent or a polymeric surface layer laminated onto the base layer. The invention includes a method for preparing the article wherein a homogeneous melt of polymer and chlorhexidine is prepared by twin screw compounding and the melt is extruded to give a medical article having bulk distributed chlorhexidine.
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Citations
14 Claims
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1. A method for preparing a medical article comprising:
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a) preparing a blend of an anti-infective agent comprising chlorhexide, with pellets of a base polymer having a water absorption of at least 0.6% by weight; b) heating said blend to a temperature from about 160°
C. to about 250°
C. and for a sufficient time to form a homogenous melt of said polymer having said anti-infective agent uniformly distributed therein; andc) extruding said melt through a die to form a medical article having said anti-infective agent bulk distributed throughout said polymer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for preparing a medical article comprising preparing a homogeneous melt of a polymer having a water absorption of at least 0.6% by weight and an anti-infective agent at a temperature range from about 160°
- C. to about 250°
C. and extruding said melt through a die to form a medical article having said agent bulk distributed throughout said polymer.
- C. to about 250°
Specification