Methods of inhibiting sexual precocity

• US 5,451,590 A
• Filed: 12/21/1993
• Issued: 09/19/1995
• Est. Priority Date: 12/21/1993
• Status: Expired due to Term

• Current Assignee: Eli Lilly and Company
• Original Assignee: Eli Lilly and Company
• Inventors: Dodge, Jeffrey A.
• Primary Examiner(s): FAY, ZOHREH A
• Application Number:
  US08/171,393
• Time in Patent Office: 637 Days
• Field of Search: 514/320, 514/324
• US Class Current: 514/324
• CPC Class Codes: A61K 31/38 having sulfur as a ring hetero atom
• CPC Class Codes: A61K 31/40 having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• CPC Class Codes: A61K 31/445 Non condensed piperidines, e.g. piperocaine
• CPC Class Codes: A61P 13/02 of urine or of the urinary tract, e.g. urine acidifiers
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives

Abstract

A method of inhibiting sexual precocity comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R¹ and R³ are independently hydrogen, --CH₃, ##STR2## wherein Ar is optionally substituted phenyl; R² is selected from the group consisting of pyrrolidine, hexamethyleneamino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.

Claims

1. A method of inhibiting sexual precocity comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR5## wherein R¹ and R³ are independently hydrogen, --CH₃, ##STR6## wherein Ar is optionally substituted phenyl;

R² is selected from the group consisting of pyrrolidine, hexamthylenemino, and piperidino;

or a pharmaceutically acceptable salt of solvate thereof.

2. The method of claim 1 wherein said compound is the hydrochloride salt thereof.

3. The method of claim 1 wherein said compound ##STR7## or its hydrochloride salt.

4. The method of claim 1 where said human is under the age of eighteen.

5. The method of claim 1 wherein said human is also administered a progestin or LHRH agonist.