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Laminated barriers for tissue implants

  • US 5,453,278 A
  • Filed: 01/28/1994
  • Issued: 09/26/1995
  • Est. Priority Date: 07/24/1991
  • Status: Expired due to Fees
First Claim
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1. A composite laminated porous structure for implanting living cells in a host tissue comprisinga first membrane element having a first characteristic beneficial for survival of the implanted cells,a second membrane element having second characteristic, different than the first characteristic, beneficial for survival of the implanted cells,the characteristic of one of the membrane elements including a flux value that supports transfer of nutrients and waste materials through the one membrane element sufficient to sustain metabolic processes of the implanted cells,adhesive material comprising a mixture of a resin and a solvent applied to create a pattern of spaced apart filaments that forms an interface between the first and second membrane elements, the interface having been melted in place by application of heat and solidified by cooling to secure the first and second membrane elements together into a composite laminated structure having tensile strength to withstand physiological stresses when implanted in the host tissue, the interface also retaining the characteristics of both membrane elements so that the characteristics of each membrane element is imparted to the composite structure.

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