Method for measuring the myocardial electrical impedance spectrum

• US 5,454,377 A
• Filed: 10/08/1993
• Issued: 10/03/1995
• Est. Priority Date: 10/08/1993
• Status: Expired due to Fees

• Current Assignee: Ohio State University, Tyco Submarine Systems Ltd.
• Original Assignee: Ohio State University
• Inventors: Liu, Alan Y., Hartzler, Alan W., Dzwonczyk, Roger R.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): NASSER, ROBERT L
• Application Number:
  US08/134,288
• Time in Patent Office: 725 Days
• Field of Search: 128/734, 607/17, 607/24
• US Class Current: 600/547
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: A61B 5/413 Monitoring transplanted tissue or organ, e.g. for possible rejection reactions after a transplant
• CPC Class Codes: A61B 5/7257 using Fourier transforms

Abstract

A method for measuring the complex impedance spectrum of a portion of the myocardium by placing two electrodes on a portion of the myocardium and applying a current pulse to the electrodes to generate a voltage response between the electrodes. Both the current pulse and voltage response are sampled and digitized and then a Fast fourier transform is taken of both the current pulse and the voltage response to obtain a complex current pulse spectrum and a complex voltage response spectrum. Next, the complex voltage response spectrum is divided by the complex current pulse spectrum to obtain the complex impedance spectrum.

Claims

1. A method for measuring a complex impedance spectrum of a portion of myocardium between two electrodes, the method comprising:

(a) applying a current pulse to the electrodes to generate a voltage response between the electrodes;

(b) sampling and digitizing both the applied current pulse and the voltage response;

(c) performing a fast Fourier transform upon both the digitized current pulse and the digitized voltage response to obtain a complex current pulse spectrum and a complex voltage response spectrum;

(d) dividing the complex voltage response component for each frequency in the voltage response spectrum by the complex current pulse component for each corresponding frequency in the current pulse spectrum to obtain the complex impedance spectrum; and

(e) displaying complex impedance spectrum data for analysis for a physician.

2. A method in accordance with claim 1 wherein said displaying step further comprises displaying the absolute value of a complex magnitude component for each of a plurality of frequency components of the complex impedance spectrum.

3. A method in accordance with claim 2 including displaying the absolute values of the magnitude component for each of a plurality of frequency components of the complex impedance spectrum as a function of frequency.

4. A method in accordance with claim 1 wherein said displaying step further comprises displaying a complex phase angle component value for a plurality of frequency components of the complex impedance spectrum.

5. A method in accordance with claim 1 wherein the current pulse has approximately a 10 microamp amplitude and approximately a 0.15 millisecond duration.

6. A method in accordance with claim 5 and further comprising after each current pulse, applying a second, depolarizing pulse having an amplitude and duration substantially equal to the preceding current pulse, but in opposite polarity.