Transfer adaptors

• US 5,454,409 A
• Filed: 06/02/1994
• Issued: 10/03/1995
• Est. Priority Date: 02/15/1991
• Status: Expired due to Term

• Current Assignee: Waverly Pharmaceutical Ltd (Teva Pharmaceutical Industries Limited)
• Original Assignee: Waverly Pharmaceutical Ltd (Teva Pharmaceutical Industries Limited)
• Inventors: Wilson, David, Rose, Howard, McAffer, Ian G. C.
• Primary Examiner(s): Recla, Henry J.
• Assistant Examiner(s): Walczak, David J.
• Application Number:
  US08/253,429
• Time in Patent Office: 488 Days
• Field of Search: 141/329, 141/27, 141/84, 141/330, 141/312, 141/363, 141/364, 141/365, 141/375, 141/382, 141/83, 141/18, 604/403, 604/415, 604/408, 604/410, 604/411, 604/412, 604/414, 604/416, 604/905, 604/240, 604/243, 604/283, 128/912, 128/203.21
• US Class Current: 141/329
• CPC Class Codes: A61J 1/1406 Septums, pierceable membranes
• CPC Class Codes: A61J 1/1425 Snap-fit type
• CPC Class Codes: A61J 1/1468 Containers characterised by specific material properties
• CPC Class Codes: A61J 1/1487 with friction fit, e.g. connecting tubes directly to a protruding port
• CPC Class Codes: A61J 1/18 Arrangements for indicating condition of container contents, e.g. sterile condition
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents

Abstract

The present invention relates to a transfer adaptor for use with a vial containing ingredients to be reconstituted, an ampoule containing a reconstituting fluid and a syringe, the adaptor being made preferably of plastic, thereby cutting down on the wasteful use of many needles and reducing the problem of sharps.

Claims

1. A transfer adaptor adapted for fluid communication

i) between a vial having septum and a reservoir having a female opening and thereafter

ii) between said vial and a syringe having a male exit nozzle,

said adaptor comprising:

a cannula, said cannula having a proximal end and a distal end, said distal end being adapted to pierce said septum to permit passage of said adaptor into said vial; and

a collar located between said proximal and distal ends to prevent said adaptor from passing entirely into said vial through said septum;

and wherein said proximal end of said cannula is configured so as;

a) to provide a male receptor, said male receptor being adapted to receive said female opening of said reservoir, and

b) to provide a female receptor located within said male receptor, said female receptor being adapted to receive said male exit nozzle of said syringe.

2. The transfer adaptor of claim 1, wherein said reservoir is a blow-fill seal ampoule.

3. The transfer adaptor of claim 1, wherein said male receptor of said transfer adaptor fits sealingly into said female opening of said reservoir.

4. The transfer adaptor of claim 1, wherein said male receptor of said transfer adaptor is contoured such that said male receptor is adapted to fit exactly into said female opening of said reservoir.

5. The transfer adaptor of claim 1, wherein said male receptor has base and a tip, and is elongated so that said base of said receptor is broader than said female opening of said reservoir, and said tip of said receptor is narrower than said opening.

6. The transfer adaptor of claim 1, wherein said receptors, said opening of said reservoir and said nozzle of said syringe are all essentially luer-shaped.

7. The transfer adaptor of claim 1, wherein said cannula has an internal bore closed at the distal end of the cannula and having an exit through a side of the cannula.

8. The transfer adaptor of claim 1, wherein said entire transfer adaptor is formed as an integral, injection-molded unit.

9. The transfer adaptor of claim 1, wherein said female receptor of said transfer adaptor is contoured to fit exactly with said male exit nozzle of said syringe.

10. The transfer adaptor of claim 1, wherein said collar is sufficiently wide to cover said entire septum of said vial.

11. The transfer adaptor of claim 10, wherein said vial has a septum-retaining collar having a wall, and said collar of said adaptor is further provided with a dependent flange which is adapted to at least partially surround said wall of said septum-retaining collar on said vial.

12. The transfer adaptor of claim 11, wherein at said extent of said flange there is provided an inwardly directed finger which snaps over said septum-retaining collar in use.

13. The transfer adaptor of claim 11, wherein said flange extends axially beyond said distal end of said cannula.

14. The transfer adaptor of claim 1, wherein an upwardly directed wall is provided about the male and female receptors of said transfer adaptor.

15. The transfer adaptor of claim 14, wherein said upstanding wall is provided with a cover.

16. The transfer adaptor of claim 1, wherein said adaptor and said reservoir form a unit, said ampoule being fitted with a septum adapted to be punctured by said male receptor of said transfer adaptor when said unit is forced onto said vial.

17. The transfer adaptor of claim 1 wherein said cannula has a closed end and being provided with an opening in a side wall thereof.

18. An injection reconstitution system comprising a blow-fill-seal ampoule which contains liquid and a transfer adaptor as defined in claim 1, said ampoule having a female opening covered by a removable cap, said opening being mateable with said male receptor of said transfer adaptor.

19. A method of preparing an injectable composition, said method comprising transferring a reconstitution liquid from a blow-fill-seal ampoule to a vial containing an unreconstituted composition by means of a transfer adaptor as defined in claim 1, and subsequently drawing reconstituted injectable composition into a syringe from said vial via said transfer adaptor.

20. A transfer adaptor adapted for fluid communication between a vial and, independently, a reservoir and a syringe, wherein the vial includes a septum, the reservoir includes an opening extending therethrough and the syringe includes an exit nozzle attached thereto, the adaptor comprising a cannula, the cannula having a proximal end and a distal end, the distal end being adapted to pierce the septum of the vial to permit passage of the adaptor into the vial;

and a shroud disposed between the proximal and distal ends adapted for engagement with the vial and to prevent the adaptor from passing entirely into the vial during engagement with the vial and wherein the proximal end of the cannula comprises;

a) a first receptor formed to receive the opening of the reservoir, and

b) a second receptor disposed within the first receptor and integral therewith for receiving the exit nozzle of the syringe.