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Method for inducing periodontal tissue regeneration

  • US 5,455,041 A
  • Filed: 09/13/1993
  • Issued: 10/03/1995
  • Est. Priority Date: 09/13/1993
  • Status: Expired due to Fees
First Claim
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1. A method for inducing periodontal regeneration in a wound of a mammal with periodontal disease or other condition requiring periodontal regeneration, said method induces soft tissue, cementum and alveolar bone healing of a type characteristic of the anatomy and architecture of undiseased periodontium, comprising the steps of:

  • a) treating the root surface in the wound with mechanical instrumentation and a composition comprising a demineralizing agent;

    b) applying a therapeutically effective amount of a growth factor directly to the treated root surface, wherein said growth factor is one or more factors selected from the group consisting of platelet-derived growth factor in a form having two beta chain (PDGF-BB), platelet-derived growth factor in a form having an alpha and a beta chain (PDGF-AB) and IGF-I;

    c) inserting a periodontal barrier, wherein the barrier is positioned between the gingival tissue and the root surface treated according to steps. a) and b) to create and maintain a space for regeneration, and wherein the barrier is selected the group consisting of a membrane, a biodegradable polymer, and a biocompatible porous material; and

    d) closing the wound to allow for regeneration.

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