Method for oral spray administration of caffeine

• US 5,456,677 A
• Filed: 08/22/1994
• Issued: 10/10/1995
• Est. Priority Date: 08/22/1994
• Status: Expired due to Fees

• Current Assignee: John E. Spector
• Original Assignee: John E. Spector
• Inventors: Spector, John E.
• Primary Examiner(s): Green, Randall L.
• Assistant Examiner(s): Polutta, Mark O.
• Application Number:
  US08/293,838
• Time in Patent Office: 414 Days
• Field of Search: 604/290, 604/310, 604/311, 128/200.14, 128/200.23, 424/25.43, 424/58
• US Class Current: 604/290
• CPC Class Codes: A61K 31/522 having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• CPC Class Codes: A61K 9/006 Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
• CPC Class Codes: A61M 15/009 using medicine packages with incorporated spraying means, e.g. aerosol cans pocket atomiser of the injector type A61M11/08
• CPC Class Codes: A61M 35/003 Portable hand-held applicators having means for dispensing or spreading integral media hand-held massage devices with liquid delivery A61H7/003

Abstract

A method and apparatus are disclosed for easily and conveniently self-administering caffeine in combination with a breath freshener. Caffeine, which has important physiological effects as a central nervous system stimulant, is readily, conveniently and effectively administered to humans in a manner neither heretofore recognized nor disclosed, and which uniquely provides for very rapid onset of the stimulatory physiological effect to the user. The caffeine, with a carrier and in combination with a breath freshener, is dispensed as a liquid spray or stream directly onto a person'"'"'s tongue, from which it is rapidly absorbed in the human system by swallowing and absorption from the intestinal tract or by absorption through the buccal membranes. The caffeine is administered on an as-needed basis in daily quantities of preferably up to 200 mg per four hour period, through one or preferably several metered dosages. The invention is a unique administration method and device, which permits simple and convenient administration of caffeine in a unobtrusive and effective manner on an as-needed basis, with rapid and strong stimulatory effect.

Claims

1. A method for administering caffeine to a person from a dispensing device which comprises:

incorporating caffeine in at least a predetermined quantity effective to accomplish CNS stimulation in a human and a breath freshening compound into a physiologically acceptable liquid carrier to form a mixture;

placing the mixture into said dispensing device from which said mixture can be ejected as an atomized spray or as a liquid stream;

operating said device to eject at least one metered amount of said spray or stream of mixture comprising at least 5 mg of caffeine directly onto said person'"'"'s tongue; and

continuing to convey said spray or stream in metered doses onto said tongue for a period of time sufficient to administer at least 50 mg of caffeine, thereby promoting CNS stimulation to said person by assimilation into said person'"'"'s body by absorption through buccal membranes.

2. A method as in claim 1 wherein said caffeine is administered in cumulative daily quantities of not more than 1600 mg.

3. A method as in claim 2 wherein said caffeine is administered in individual doses of no more than 200 mg/dose.

4. A method as in claim 3 wherein said caffeine is administered in a cumulative quantity of not more 200 mg per four hour period.

5. A method as in claim 1 wherein said device comprises a mechanically operated pump which generates and ejects said liquid spray or stream.

7. A method as in claim 1 wherein said breath freshener comprises a composition which also imparts a palatable flavor to said mixture.

8. A method as in claim 1 wherein said mixture further comprises sodium benzoate.

9. A method as in claim 1 wherein said carrier is selected from the group consisting of water, glycerin, ethanol, fruit juices, edible oils and the like.

10. A method as in claim 9 wherein said carrier is purified water.

6. A method as in claim I wherein said device comprises a gas pressure operated pump which generates and ejects said liquid spray or stream.