Thieno[1,5]benzoidiazepine use

• US 5,457,101 A
• Filed: 06/03/1994
• Issued: 10/10/1995
• Est. Priority Date: 06/03/1994
• Status: Expired due to Fees

• Current Assignee: Eli Lilly and Company
• Original Assignee: Eli Lilly and Company
• Inventors: Greenwood, Beverley, Nelson, David L. G.
• Primary Examiner(s): Goldberg, Jerome D.
• Application Number:
  US08/253,658
• Time in Patent Office: 494 Days
• Field of Search: 514/220
• US Class Current: 514/220
• CPC Class Codes: A61K 31/5513 1,4-Benzodiazepines, e.g. diazepam or clozapine
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/12 Antidiarrhoeals
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The compound 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno-[2,3-b][1,5]benzodiazepine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of certain gastrointestinal disorders.

Claims

1. A method for treating a mammal, suffering from a Functional Bowel Disorder, which comprises administering an effective amount of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno-[2,3-b][1,5]benzodiazepine, or an acid addition salt thereof.

2. A method of claim 1 for treating a mammal, suffering from a Functional Bowel Disorder selected from the group consisting of irritable bowel syndrome, hypermotility, ichlasia, hypertonic lower esophogeal sphinctor, tachygastria, constipation, and hypermotility associated with irritable bowel syndrome.

3. A method of claim 2 for treating a mammal, suffering from a Functional Bowel Disorder selected from the group consisting of irritable bowel syndrome and hypermotility associated with irritable bowel syndrome.

4. A method of claim 1 wherein the effective amount is from 1 to 20 mg per day of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno-[2,3-b][1,5]benzodiazepine, or an acid addition salt thereof.