Cerebral biopotential analysis system and method
First Claim
1. A method of generating a diagnostic index for quantifying the presence or absence of a biopotential phenomena, said method comprising the steps of:
- acquiring electrical signals from a living body, said electrical signals representing the biopotential phenomena;
generating spectral values from said acquired electrical signals;
sorting said spectral values into at least one predetermined bin of ranges of spectral values;
selecting at least one variable representative of spectral values in each of said at least one bin;
multiplying said selected at least one variable in each of said at least one bin by a predetermined coefficient to obtain a bin product;
summing said bin products to obtain a diagnostic index which represents a degree of presence or absence of said phenomena.
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Abstract
Disclosed is a system and method to derive a diagnostic index indicative of a selected cerebral phenomena which obtains 19 unipolar EEG signals from regions of interest on both the left and right hemispheres of a subject'"'"'s brain. The system uses high-gain, low-noise amplifiers to maximize the dynamic range for low energy wave components of the signals. Band-pass filtering is used to reduce noise and to avoid aliasing. The system applies commonly used digital signal processing (DSP) techniques to digitize, to low-pass filter (100 Hz), and to decimate the signals. Power spectral, bispectral, and higher-order spectral processing is then performed. In a preferred embodiment, the system divides the most recent 63 seconds of digitized EEG data from each lead into 60 4-second intervals, each with 3 seconds of overlap with the previous interval. For a selected set of derived leads, the system produces auto power spectrum, autobispectrum, and auto higher-order spectrum variables, by using either a Fast Fourier Transform (FFT) based approach or a parametric approach. Any pair of leads can be combined to compute cross power spectrum, cross bispectrum, and cross higher-order spectrum variables. The spectral values are separated into bins and a value representative of the bin is selected or computed and then each value is multiplied by a predetermined coefficient. The resulting products are summed to arrive at the diagnostic index.
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Citations
22 Claims
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1. A method of generating a diagnostic index for quantifying the presence or absence of a biopotential phenomena, said method comprising the steps of:
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acquiring electrical signals from a living body, said electrical signals representing the biopotential phenomena; generating spectral values from said acquired electrical signals; sorting said spectral values into at least one predetermined bin of ranges of spectral values; selecting at least one variable representative of spectral values in each of said at least one bin; multiplying said selected at least one variable in each of said at least one bin by a predetermined coefficient to obtain a bin product; summing said bin products to obtain a diagnostic index which represents a degree of presence or absence of said phenomena. - View Dependent Claims (2, 3, 4, 5, 6, 7, 9, 10, 11)
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8. The method of generating a diagnostic index of claim t wherein said at least one variable ms the maximum value of the spectral values in said bin.
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12. A system for generating a diagnostic index for quantifying the presence or absence of a biopotential phenomena, said system comprising:
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means for acquiring electrical signals from a living body, said electrical signals representing the biopotential phenomena; means for generating spectral values from said acquired electrical signals; means for sorting said spectral values into at least one predetermined bin of ranges of spectral values; means for selecting at least one variable representative of the spectral values in each of said at least one bin; means for multiplying said selected at least one variable in each of said at least one bin by a predetermined coefficient to obtain a bin product; means for summing said bin products to obtain a diagnostic index which represents a degree of presence or absence of said phenomena. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification