Porous balloon for selective dilatation and drug delivery

• US 5,458,568 A
• Filed: 09/17/1993
• Issued: 10/17/1995
• Est. Priority Date: 05/24/1991
• Status: Expired due to Term

• Current Assignee: Vention Medical Advanced Components, Inc. (Nordson Corporation)
• Original Assignee: Cortrak Medical Incorporated
• Inventors: Knudson, Mark B., Shimada, Jin, Racchini, Joel R., Hildebrand, Keith R., Shapland, James E.
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): GRING, NOELLE K
• Application Number:
  US08/123,374
• Time in Patent Office: 760 Days
• Field of Search: 604/19-22, 604/95-103, 601/2
• US Class Current: 604/19
• CPC Class Codes: A61M 16/0481 through the cuff wall
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 25/104 used for angioplasty
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/306 Arrangements where at least part of the apparatus is introduced into the body
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428
• CPC Class Codes: A61N 2001/0585 Coronary sinus electrodes

Abstract

A drug delivery apparatus and method for delivering a drug locally to internal body tissue. The invention contemplates positioning a drug delivery device in a body passageway or within body tissue and then selectively wetting a membrane within the device, making the membrane permeable and allowing transport of a drug across the membrane and into the passageway wall or body tissue.

Claims

1. A method of delivering a drug to internal body tissue, comprising the steps of:

(a) providing a catheter having a non-wetted and controllably permeable porous membrane proximate said distal end of said catheter, said membrane having a predetermined pore size and defining a drug delivery chamber at said distal end of said catheter;

(b) positioning said drug delivery chamber proximate said internal body tissue;

(c) wetting said porous membrane with a fluid thereby making said membrane permeable, said fluid having a predetermined surface tension and a predetermined contact angle with the porous membrane; and

(d) transporting said drug from said delivery chamber to said internal body tissue across said porous membrane.

2. The method of claim 1, wherein said step of positioning further comprises positioning said drug delivery chamber in an internal elongated passageway proximate said internal body tissue.

3. The method of claim 2, further comprising the step of dilating said passageway by expanding said porous membrane.

4. The method of claim 1, wherein said step of wetting further comprises providing a fluid to said drug delivery chamber through said fluid delivery lumen.

5. The method of claim 4, wherein providing said fluid further comprises providing a wetting agent in said fluid.

6. The method of claim 5, wherein providing said wetting agent further comprises providing a surfactant in said fluid.

7. The method of claim 4, wherein said step of wetting further comprises pressurizing said fluid.

8. The method of claim 4, wherein said step of wetting further comprises providing a voltage gradient from said fluid in said drug delivery chamber to said internal body tissue across said porous membrane.

9. The method of claim 1, wherein said step of transporting further comprises providing a voltage gradient from said drug delivery chamber to said internal body tissue across said porous membrane.