Implantable device and materials

• US 5,458,632 A
• Filed: 07/30/1993
• Issued: 10/17/1995
• Est. Priority Date: 08/10/1990
• Status: Expired due to Term

• Current Assignee: Pacesetter AB
• Original Assignee: Pacesetter AB
• Inventors: Saeger, Stefanie, Preidel, Walter
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): SCHAETZLE, KENNEDY
• Application Number:
  US08/099,990
• Time in Patent Office: 809 Days
• Field of Search: 623/1, 607/120, 607/121, 128/DIG. 22
• US Class Current: 607/121
• CPC Class Codes: A61L 33/0047 Enzymes, e.g. urokinase, streptokinase

Abstract

The invention relates to implantable devices and materials, in which at least one part of the surface is provided with a tissue-plasminogen activator (t-PA). In this way, inflammatory reactions of the body and the formation of fibrous capsules, which ordinarily occur after implantation, are avoided or reduced.

Claims

1. An article which is implantable in a human body having a surface, at least a portion of said surface having a tissue-plasminogen activator adsorbed directly thereon, the tissue-plasminogen activator being directly adsorbed into the surface without being chemically bonded to any polymer on the surface and without being bonded to the surface, and said adsorbed tissue-plasminogen activator being releasable and detachable from the surface of the article upon implantation in the body and upon contact with blood or lymph fluid.

2. The article according to claim 1 wherein the article is a pacemaker having at least one electrode and wherein the tissue-plasminogen activator is adsorbed into a surface of the at least one electrode.

3. The article according to claim 1 wherein the article is a pacemaker having a housing and wherein the tissue-plasminogen plasminogen activator is adsorbed into an outer surface of said housing.

4. The article according to claim 1 wherein the article is a catheter.

5. The article according to claim 1 wherein the article is a stimulating electrode of a pacemaker.