Lipophilic, aminohydrolase-activated prodrugs
First Claim
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1. A compound of the formula:
- ##STR10## wherein A is F;
B is H;
Y is H or NH2 ; and
X is selected from the group consisting of halogen, NHR or OR, whereinR is C1-8 alkyl, straight chain or branched chain, and NROR, wherein Ris H or C1-8 alkyl, straight chain or branched chain.
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Abstract
The present invention relates, in general, to prodrugs. In particular, the present invention relates to lipophilic, aminohydrolase-activated, anti-viral nucleoside prodrug compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds.
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Citations
18 Claims
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1. A compound of the formula:
- ##STR10## wherein A is F;
B is H; Y is H or NH2 ; and X is selected from the group consisting of halogen, NHR or OR, wherein R is C1-8 alkyl, straight chain or branched chain, and NROR, wherein R is H or C1-8 alkyl, straight chain or branched chain. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
- ##STR10## wherein A is F;
Specification