Method and apparatus for non-invasive detection of physiological chemicals, particularly glucose
First Claim
1. A method for non-invasive quantitative detection of a physiological chemical in a test subject comprising the steps of:
- (a) irradiating a portion of the test subject with near-infrared radiation such that the radiation is transmitted through or reflected from the test subject;
(b) collecting data concerning the transmitted or reflected infrared radiation using a detector;
(c) digitally filtering the collected data to isolate a portion of the data indicative of the physiological chemical; and
(d) determining the amount of physiological chemical in the test subject by applying a defined mathematical model to the digitally filtered data.
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Accused Products
Abstract
Non-invasive measurements of physiological chemicals such as glucose are made using infrared radiation and a signal processing system that permits the construction of a device suited for home use. The level of a selected physiological chemical in a test subject is determined in a non-invasive and quantitative manner by a method comprising the steps of: (a) irradiating a portion of the test subject with near-infrared radiation such that the radiation is transmitted through or reflected from the test subject; (b) collecting data concerning the transmitted or reflected infrared radiation using a detector; (c) digitally filtering the collected data to isolate a portion of the data indicative of the physiological chemical; and (d) determining the amount of physiological chemical in the test subject by applying a defined mathematical model to the digitally filtered data. The data collected may be in the form of an absorbance spectrum, i.e., a representation of the variation in absorbance as a function of wavelength; or in the form of an interferogram, i.e., a representation of infrared light intensity as a function of the retardation of the moving mirror in the interferometer, and thus of time.
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Citations
20 Claims
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1. A method for non-invasive quantitative detection of a physiological chemical in a test subject comprising the steps of:
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(a) irradiating a portion of the test subject with near-infrared radiation such that the radiation is transmitted through or reflected from the test subject; (b) collecting data concerning the transmitted or reflected infrared radiation using a detector; (c) digitally filtering the collected data to isolate a portion of the data indicative of the physiological chemical; and (d) determining the amount of physiological chemical in the test subject by applying a defined mathematical model to the digitally filtered data. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A device for measurement of glucose concentration in a sample being irradiated with near infrared radiation comprising:
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(a) means for collecting data concerning near-infrared radiation transmitted through or reflected from the sample; (b) means for digitally filtering the collected data to isolate a portion of data indicative of glucose; (c) means for applying a defined mathematical model to the digitally filtered data, whereby the amount of glucose in the test subject is determined; and (d) means for reporting the amount of glucose in the sample.
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20. An apparatus for the non-invasive measurement of one or more physiological chemicals in a test subject, comprising,
(a) means for irradiating a portion of the surface of the test subject with near-infrared radiation such that transmitted or reflected near-infrared radiation is available for collection; -
(b) means for collecting data concerning the transmitted or reflected near-infrared radiation; (c) means for digitally filtering the collected data to isolate a portion of data indicative of the physiological chemical; (d) means for applying a defined mathematical model to the digitally filtered data, whereby the amount of chemical in the test subject is determined; and (e) means for reporting the amount of chemical in the sample.
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Specification