Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist
First Claim
1. A device for eliciting cardiovascular responses in a mammal similar to cardiovascular responses elicited by aerobic exercise which comprises:
- (a) drug delivery system for administering an exercise simulating agent into said mammal'"'"'s bloodstream;
(b) infusion control system for controlling infusion of said exercise simulating agent into the bloodstream of said mammal which is operatively connected to said delivery system; and
(c) monitoring system connected to said mammal to measure response level of said mammal to said exercise simulating agent which is operatively connected to said drug delivery system and infusion control system such that infusion of exercise simulating agent may be feedback-controlled to obtain a preselected range of responses of said mammal to said exercise simulating agent, said preselected range of responses being varied as a function of time by the infusion control system.
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Abstract
Methods and devices for the diagnosis, evaluation and treatment of coronary artery disease (CAD) by means of a closed-loop drug delivery system that delivers an exercise simulating agent, including novel exercise simulating agents which elicit both acute and adaptive cardiovascular responses similar to those elicited by aerobic activity are provided. The acute responses to the exercise simulating agent are used to diagnose and evaluate CAD in lieu of the acute responses to aerobic exercise. Due to their adaptive responses these compounds may be used to treat CAD in lieu of the adaptive responses caused by aerobic exercise training or to treat other conditions where the adaptive responses caused by aerobic exercise are desirable.
128 Citations
24 Claims
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1. A device for eliciting cardiovascular responses in a mammal similar to cardiovascular responses elicited by aerobic exercise which comprises:
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(a) drug delivery system for administering an exercise simulating agent into said mammal'"'"'s bloodstream; (b) infusion control system for controlling infusion of said exercise simulating agent into the bloodstream of said mammal which is operatively connected to said delivery system; and (c) monitoring system connected to said mammal to measure response level of said mammal to said exercise simulating agent which is operatively connected to said drug delivery system and infusion control system such that infusion of exercise simulating agent may be feedback-controlled to obtain a preselected range of responses of said mammal to said exercise simulating agent, said preselected range of responses being varied as a function of time by the infusion control system. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A system for the closed-loop administration of a drug which causes a physical response in a mammal comprising:
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(a) a drug delivery system connected to the mammal; (b) a monitor connected to the mammal capable of determining the physical response of the mammal, and (c) a control system to control the drug infusion to the mammal so as to vary the physical response as a function of time for diagnosis, the control system being connected in closed-loop fashion to the monitor and the drug delivery system. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification