Indicator tapes and methods

• US 5,460,880 A
• Filed: 06/10/1994
• Issued: 10/24/1995
• Est. Priority Date: 05/28/1992
• Status: Expired due to Term

• Current Assignee: Minnesota Mining and Manufacturing Co (3M Company)
• Original Assignee: Minnesota Mining and Manufacturing Co (3M Company)
• Inventors: Battles, Donald R., Patnode, Gregg A., D'Haese, Francois C., Morse, Dan J.
• Primary Examiner(s): Davis, Jenna L.
• Application Number:
  US08/257,947
• Time in Patent Office: 501 Days
• Field of Search: 428/913, 428/343, 428/355, 428/354, 156/327
• US Class Current: 428/354
• CPC Class Codes: A61L 2/28 Devices for testing the effectiveness or completeness of sterilisation, e.g. indicators which change colour apparatus involving enzymes or microorganisms C12M1/34; methods involving enzymes or microorganisms C12Q1/00
• CPC Class Codes: Y10S 428/913 Material designed to be responsive to temperature, light, moisture
• CPC Class Codes: Y10T 428/2848 Three or more layers
• CPC Class Codes: Y10T 428/2852 Adhesive compositions

Abstract

Sterilization indicator tapes utilizing moisture-resistant, water-dispersible, pressure sensitive adhesives are provided. The indicator tapes comprise a non-water-dispersible backing having a sterilization indicator thereon, which is coated on at least one side with the moisture-resistant, water-dispersible, pressure sensitive adhesive. The indicator tapes are useful to maintain a sterilization wrapper containing articles to be sterilized in a closed position during sterilization, and normal pre- and post-sterilization handling, while also providing a means to indicate if the wrapped articles have passed through a sterilization cycle. After use, the adhesives coating the indicator tapes disperse in aqueous alkali solutions, such as are found in commercial laundries, while the backing remains intact. Methods of making and using the indicator tapes are also provided.

Claims

1. An indicator tape comprising:

(a) a non-water-dispersible backing having opposing sides and including thereon a sterilization indicator, and;

(b) a moisture-resistant, pressure sensitive adhesive comprising an acrylate-based copolymer in combination with a plasticizer coated on at least one of the opposing sides of the backing, said pressure sensitive adhesive being dispersible upon immersion in aqueous alkali solutions and said acrylate-based copolymer comprising a blend of (a) 100 parts by weight of a copolymer of monomers of (1) about 50-85 weight percent of at least one monomeric acrylic acid ester of a nontertiary alkyl alcohol having 2-8 carbon atoms, and (2) about 50-15 weight percent of a vinyl carboxylic acid, (b) about 10 to about 250 parts by weight of a water-dispersible or water-soluble plasticizer, (c) optionally from about 0 to about 100 parts by weight of an acrylate-compatible tackifier; and

(d) sufficient alkali metal hydroxide, if any, to neutralize from 0 to 100 percent of acid moieties in the copolymer;

wherein the coated pressure sensitive adhesive exhibits sufficient adhesion to maintain a wrapped bundle of articles in a closed position during sterilization and normal pre- and post-sterilization handling.

2. An indicator tape according to claim 1, wherein the non-water-dispersible backing comprises a woven backing, a nonwoven backing, a cloth backing, a film backing, a paper backing, a foil backing, or combinations thereof.

3. An indicator tape according to claim 1, wherein the sterilization indicator comprises an indicator ink in combination with a binder, said indicator ink being capable of undergoing a color change when exposed to sterilization conditions.

4. An indicator tape according to claim 3, wherein the indicator ink comprises a steam sterilization indicator ink, an ethylene oxide sterilization indicator ink, or a combination of a steam sterilization indicator ink and an ethylene oxide sterilization indicator ink.

5. An indicator tape according to claim 4, wherein the steam sterilization indicator ink comprises a lead carbonate-sulfur indicator ink.

6. An indicator tape according to claim 3, wherein the binder comprises an acrylate binder.

7. An indicator tape according to claim 3, wherein the indicator ink and binder are applied to the substrate by gravure printing.

8. An indicator tape according to claim 1, wherein the monomeric acrylic acid ester of a nontertiary alkyl alcohol comprises butyl acrylate and the vinyl carboxylic acid comprises acrylic acid.

9. An indicator tape according to claim 8, wherein the copolymer comprises 75 weight percent butyl acrylate and 25 weight percent acrylic acid.

10. An indicator tape according to claim 1, wherein the plasticizer is selected from the group consisting of a free acid of a complex organic phosphate ester, a sodium salt of a complex organic phosphate ester, a colophony ester, or a combination thereof.

11. An indicator tape according to claim 10, wherein the plasticizer comprises a poly(oxy-1,2-ethandiyl), alpha-(nonylphenyl)-omega-hydroxy-phosphate ester.

12. An indicator tape according to claim 1, wherein the backing exhibits sufficient strength that it will not tear during sterilization and normal pre- and post-sterilization handling.

13. An indicator tape according to claim 1, wherein the backing comprises a paper backing saturated with a strengthening agent.

14. An indicator tape according to claim 13, wherein the strengthening agent comprises a rubber-based strengthening agent.

15. An indicator tape according to claim 13, wherein the paper backing further includes a moisture-resistant agent coated thereon.

16. A method of using an indicator tape as a wrapper closure comprising:

(a) providing an indicator tape comprising a non-water-dispersible backing having opposing sides and including thereon a sterilization indicator, with a moisture-resistant, pressure sensitive adhesive coated on at least one of the opposing sides of the backing, said pressure sensitive adhesive being dispersible upon immersion in aqueous alkali solutions and said acrylate-based copolymer comprising a blend of (a) 100 parts by weight of a copolymer of monomers of (1) about 50-85 weight percent of at least one monomeric acrylic acid ester of a nontertiary alkyl alcohol having 2-8 carbon atoms, and (2) about 50-15 weight percent of a vinyl carboxylic acid, (b) about 10 to about 250 parts by weight of a water-dispersible or water-soluble plasticizer, (c) optionally from about 0 to about 100 parts by weight of an acrylate-compatible tackifier; and

(d) sufficient alkali metal hydroxide, if any, to neutralize from 0 to 100 percent of acid moieties in the copolymer; and

,

(b) applying the indicator tape to a sterilization wrapper containing a bundle of articles such that the bundle will remain substantially closed during sterilization, and normal pre- and post-sterilization handling.

17. A method of using an indicator tape according to claim 16, further comprising, laundering the sterilization wrapper after use in an aqueous alkali solution, wherein the pressure sensitive adhesive will disperse in the aqueous alkali solution leaving the non-water-dispersible backing containing the indicator ink thereon intact.