Method for the preparation of D-chiro-inositol
First Claim
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1. A method for the preparation of D-chiro-inositol from kasugamycin, comprising the steps of:
- (a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate;
(b) purifying the crude hexa-acetate to form purified hexa-acetate;
(c) deacetylating the purified hexa-acetate to form D-chiro-inositol; and
(d) isolating the D-chiro-inositol.
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Abstract
A method for the preparation of D-chiro-inositol from kasugamycin, comprising the steps of:
(a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate intermediate;
(b) purifying the crude intermediate to form purified hexa-acetate intermediate;
(c) deacetylating the purified intermediate to form D-chiro-inositol; and
(d) isolating the D-chiro-inositol.
The method permits efficient, large-scale preparation of D-chiro-inositol without the need for extensive chromatographic purification of the final D-chiro-inositol product.
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Citations
27 Claims
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1. A method for the preparation of D-chiro-inositol from kasugamycin, comprising the steps of:
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(a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate; (b) purifying the crude hexa-acetate to form purified hexa-acetate; (c) deacetylating the purified hexa-acetate to form D-chiro-inositol; and (d) isolating the D-chiro-inositol. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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Specification