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Transdermal drug delivery by electroincorporation of vesicles

  • US 5,464,386 A
  • Filed: 09/22/1994
  • Issued: 11/07/1995
  • Est. Priority Date: 08/17/1992
  • Status: Expired due to Term
First Claim
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1. A method of molecular delivery through a surface tissue, comprising the steps of:

  • selecting a quantity of molecules to be delivered through the surface tissue;

    selecting a quantity of vesicles as carriers;

    encapsulating said molecules in said vesicles;

    contacting a selected surface area of the surface tissue with a quantity of said vesicles; and

    applying a pulsed electric field of sufficient amplitude and duration to induce pores in the surface tissue and to induce transport of said vesicles through said pores into a underlying tissue to enable diffusion of said molecules into the tissue.

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