Syringe assembly for the storage and application of a biological multi-component material

• US 5,464,396 A
• Filed: 09/22/1994
• Issued: 11/07/1995
• Est. Priority Date: 10/18/1993
• Status: Expired due to Term

• Current Assignee: Immuno Aktiengesellschaft
• Original Assignee: Immuno Aktiengesellschaft
• Inventors: Eder, Helmut, Pfaffenbichler, Peter, Hantak, Edith, Granser, Manfred, Moser, Franz, Habison, Georg, Barta, Helmut
• Primary Examiner(s): YASKO JR, JOHN D
• Application Number:
  US08/310,404
• Time in Patent Office: 411 Days
• Field of Search: 604/191, 604/82, 604/187, 604/218, 604/310, 604/311
• US Class Current: 604/191
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 2017/00495 for two-component glue
• CPC Class Codes: A61M 2005/3104 Caps for syringes without needle
• CPC Class Codes: A61M 2005/31508 provided on the piston-rod
• CPC Class Codes: A61M 2207/00 Methods of manufacture, assembly or production
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: A61M 5/5066 Means for preventing re-use by disconnection of piston and piston-rod
• CPC Class Codes: B05C 17/00516 Shape or geometry of the outlet orifice or the outlet element
• CPC Class Codes: B05C 17/00593 Hand tools of the syringe type
• CPC Class Codes: B65D 81/325 Containers having parallel or coaxial compartments, provided with a piston or a movable bottom for discharging contents

Abstract

There is disclosed a syringe assembly for the storage and application of a biological multi-component material. Its assembly parts are a syringe device including several parallel syringe bodies interconnected by a connection part, which syringe bodies are filled with the individual components of the multi-component material, include coni and are closed by pistons; an actuation device for this syringe device, which includes piston rods associated with the pistons and a common grip element; and a dispensing element to be attached to the coni of the syringe bodies. The filled syringe bodies, which are closed by separate piston plugs, constitute a one-piece syringe unit with the connection part. The connection part leaves a recess between the syringe bodies on one of the ends of the syringe unit for receiving a protection means shielding off the other syringe body/ies when filling the syringe bodies. The grip element is connected in one piece with the piston rods, thereby forming a one-piece piston rod unit separate from the syringe unit including the piston plugs.

Claims

1. A syringe assembly for storing and applying a biological multi-component material, comprising as separate assembly components:

(a) a syringe device including at least two parallel syringe bodies ending in coni and each filled with one of said multi-component material, a connection part connecting said syringe bodies, and piston plugs closing said syringe bodies in the filled state;

(b) an actuation means including piston rods associated with said piston plugs and a common grip element; and

(c) a dispensing element capable of being attached to said coni of said syringe bodies;

wherein

said syringe bodies, after having been filled and separately closed by said piston plugs, constitute a one-piece syringe unit with said connection part,

said connection part, on one end of said syringe unit, leaves a recess between said syringe bodies, and

said grip element is connected in one piece with said piston rods, thus forming a one-piece piston rod unit separate from said syringe unit including said piston plugs.

2. A syringe assembly as set forth in claim 1, wherein said syringe unit has an end opposite said coni and said recess is provided on said end opposite said coni.

3. A syringe assembly as set forth in claim 1, wherein said syringe unit comprises X-ray-tight material at least in regions thereof.

4. A syringe assembly as set forth in claim 3, wherein said X-ray-tight material is in the form of a strip.

5. A syringe assembly as set forth in claim 1, wherein said piston rod unit comprises X-ray-tight material at least in regions thereof.

6. A syringe assembly as set forth in claim 5, wherein said X-ray-tight material is in the form of a strip.

7. A syringe assembly as set forth in claim 1, wherein said dispensing element comprises X-ray-tight material at least in regions thereof.

8. A syringe assembly as set forth in claim 7, wherein said X-ray-tight material is in the form of a strip.

9. A syringe assembly as set forth in claim 1, wherein said piston plugs are arranged for displacement within said syringe bodies by said piston rod unit only in the direction of said coni.

10. A syringe assembly as set forth in claim 1, wherein said piston plugs are made of silicone material.

29. A syringe assembly as set forth in claim 1, wherein said actuation means further comprises a reinforcement web following on said grip element and extending between said piston rods, said reinforcement web being firmly connected with said piston rods.

30. A syringe assembly as set forth in claim 1, wherein said piston rod unit is a one-piece injection-molded part.

31. A syringe assembly as set forth in claim 1, wherein said piston rod unit is comprised of an acrylonitrile-butadiene-styrene copolymer.

32. A syringe assembly as set forth in claim 1, wherein said connection part, or one end of said syringe unit, leaves a recess between said syringe bodies suited to temporarily receive a protection means therein to shield off the other of said at least two syringe bodies during filling of a respective one of said syringe bodies.

11. A syringe device for storing and applying a biological multi-component material, comprising at least two parallel syringe bodies made of a synthetic material, ending in coni and each filled with one of said multi-component material, at least one connection part adapted to connect said syringe bodies and constituting a one-piece syringe unit with said syringe bodies, and piston plugs adapted to close said syringe bodies, wherein said connection part, on one end of said syringe unit, leaves a recess between said syringe bodies.

12. A syringe device as set forth in claim 11, wherein said syringe unit has an end opposite said coni and said recess is provided on said end opposite said coni.

13. A syringe device as set forth in claim 11, wherein said connection part is comprised of at least two parallel plate-shaped connection webs extending between said syringe bodies thereby interconnecting said syringe bodies to one piece.

14. A syringe device as set forth in claim 13, wherein each of said at least two connection webs tangentially joins the respective one of said syringe bodies.

15. A syringe device as set forth in claim 11, wherein each of said syringe bodies has a syringe body external diameter and said syringe unit is flat and plate-shaped, having a thickness corresponding to said syringe body external diameter.

16. A syringe device as set forth in claim 15, wherein said syringe bodies have different cross sectional areas and constant piston stroke lengths, the cross sectional area of at least one of said syringe bodies being oval and its dimension transverse to the thickness direction of said plate-shaped syringe unit being different from that of the cross sectional area of the other of said syringe bodies.

17. A syringe device as set forth in claim 11, wherein said syringe bodies have longitudinal axes defining a median plane and said connection part is comprised of at least one connection web extending in a plate-shaped manner in accordance with said median plane and following centrally on the respective one of said syringe bodies.

18. A syringe device as set forth in claim 11, wherein the respective connection part terminates at a distance of at least 2 mm from one end of said syringe unit so as to leave said reception recess.

19. A syringe device as set forth in claim 18, wherein the respective connection part terminates at a distance of between 5 mm and 15 mm from one end of said syringe unit.

20. A syringe device as set forth in claim 18, wherein the respective connection part terminates at a distance of about 10 mm from one end of said syringe unit.

21. A syringe device as set forth in claim 11, further comprising finger grips laterally projecting from said syringe bodies and wherein said finger grips are molded directly to said syringe bodies to their rear ends.

22. A syringe device as set forth in claim 11, wherein said syringe unit is a one-piece polypropylene injection-molded part.

23. A syringe device as set forth in claim 11, wherein said at least one connection part comprises at least one inscription area.

24. A syringe device as set forth in claim 11, wherein said syringe unit comprises X-ray-tight material, at least in regions thereof.

25. A syringe device as set forth in claim 24, wherein said X-ray-tight material is in the form of a strip.

26. A syringe device as set forth in claim 11, wherein separate piston plugs are inserted in said syringe bodies after filling thereof for closing said syringe bodies.

27. A syringe device as set forth in claim 26, wherein said piston plugs are arranged for displacement only in the direction of said coni.

28. A syringe assembly as set forth in claim 26, wherein said piston plugs are made of silicone material.

33. A syringe assembly as set forth in claim 11, wherein said connection part, or one end of said syringe unit, leaves a recess between said syringe bodies suited to temporarily receive a protection means therein to shield off the other of said at least two syringe bodies during filling of a respective one of said syringe bodies.

34. A method of producing a filled sterile syringe device including at least two parallel syringe bodies filled with a biological multi-component material, a connection part adapted to connect said syringe bodies and constituting a syringe unit therewith, and piston plugs adapted to close said syringe bodies, said connection part leaving a recess between said syringe bodies on one end of said syringe unit, which method comprises the steps of

providing a sterile one-piece syringe unit, sealing each of said syringe bodies on one of its ends,

introducing a protection means into said recess for for shielding off the respective other of said at least two syringe bodies,

automatically filling each component of said biological multi-component material in the respective one of said syringe bodies on its other end in a filling station and under sterile conditions, and

closing said syringe bodies with said piston plugs being sterile.

35. A method as set forth in claim 34, wherein said syringe unit is sterilely produced and kept sterile.

36. A method as set forth in claim 34, wherein said syringe unit is sterilized after production.

37. A method as set forth in claim 34, further comprising sterilely packing said syringe device immediately upon filling with said components and closing by said piston plugs.

38. A method as set forth in claim 34, wherein several syringe units are arranged in a row and the corresponding ones of said syringe bodies are sterilely filled simultaneously while introducing respective common protection means into recesses provided between said syringe units.