Drug vial mixing and transfer device

• US 5,466,220 A
• Filed: 03/08/1994
• Issued: 11/14/1995
• Est. Priority Date: 03/08/1994
• Status: Expired due to Term

• Current Assignee: Bioject Incorporated
• Original Assignee: Bioject Incorporated
• Inventors: Brenneman, Rodney
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): GRING, NOELLE K
• Application Number:
  US08/208,620
• Time in Patent Office: 616 Days
• Field of Search: 604/56, 604/82-90, 604/92, 604/208, 604/248, 604/403, 604/407, 604/410, 604/413, 604/416, 604/411, 141/27, 141/26, 141/25, 141/94, 141/98, 141/391, 141/104
• US Class Current: 604/87
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2013 having two piercing ends
• CPC Class Codes: A61J 1/2017 having three or more piercing ends
• CPC Class Codes: A61J 1/2058 having multiple connecting ports
• CPC Class Codes: A61J 1/2062 with directional valves
• CPC Class Codes: A61J 1/2065 having aligning and guiding means
• CPC Class Codes: A61J 1/2089 Containers or vials which are to be joined to each other in order to mix their contents combinations of vial and syringe for mixing their contents A61J1/2096
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents

Abstract

A drug vial mixing and transfer device having a piercing connector or a syringe attached to the end of one or more ports with interconnecting fluid passageways. Further, the piercing connector is used to support and penetrate standard glass drug vials filled with powder or lyophilized drugs or liquid diluent, while the syringe is used to transfer liquid diluent and drug solutions between the vials and the syringe advantageously within a sealed system.

Claims

1. A drug mixing and transfer device comprising:

a base;

a valve attached to said base;

a plurality of ports with fluid passageways extending generally outwardly from said valve, said valve enabling fluid communication between the fluid passageways of said plurality of ports;

a piercing connector attached to each of said plurality of ports, said piercing connector being adapted to receive and penetrate a vial and to retain the vial in place during operation of the drug mixing and transfer device;

a retainer attached to said base and located in spaced relation to said piercing connector, said retainer being adapted to maintain the vial in spaced relation with said piercing connector prior to operation of the drug mixing and transfer device; and

a syringe attaching port having a fluid passageway and extending generally outwardly from said valve, said valve enabling fluid communication between the fluid passageway of said syringe attaching port and the fluid passageways of said plurality of ports.

2. The drug mixing and transfer device of claim 1, wherein said retainer and said base are constructed of single piece molded plastic.

3. The drug mixing and transfer device of claim 1, wherein said valve comprises a stop cock type valve.

4. The drug mixing and transfer device of claim 3, wherein said stop cock type valve further comprises:

a valve body;

a 1ever;

a generally cylindrical stem attached to said lever and generally axially and rotatably located within said valve body; and

a fluid passageway within said stem, said fluid passageway of said stem enabling fluid communication between the fluid passageways of said syringe attaching port and said plurality of ports.

5. The drug mixing and transfer device of claim 1, wherein said piercing connector further comprises:

a generally cylindrically cup shaped housing;

an annular claw attached generally annularly around the inner surface of said housing; and

a piercing cannula generally fixed axially within said housing, said cannula forming a fluid pathway through said housing that communicates with the corresponding fluid passageway of said plurality of ports.

6. The drug mixing and transfer device of claim 1, further comparing a vial mounted in said retainer and filled with either a liquid diluent, a liquid drug, or a lyophilized drug.

7. A drug mixing and transfer device comprising:

a port having a fluid passageway therethrough;

a piercing connector attached to said port to receive and penetrate a vial;

a retainer extending from said piercing connector and adapted to maintain the vial in spaced relation with said piercing connector prior to operation of the drug mixing and transfer device;

a syringe attached to said port, said syringe being in fluid communication with the fluid passageway of said port; and

a plug within said piercing connector to prevent leakage of liquid diluent from said syringe prior to operation.

8. The drug mixing and transfer device of claim 7, wherein said piercing connector further comprises:

a generally cylindrically cup shaped housing;

an annular claw attached generally annularly around inner surface of said housing; and

a piercing cannula generally fixed axially within said housing, said cannula forming a fluid pathway through said housing that communicates with the fluid passageway of said port.

9. The drug mixing and transfer device of claim 7, further comprising a vial mounted in said retainer and filled with either a liquid diluent, a liquid drug, or a lyophilized drug.

10. A drug mixing and transfer device comprising:

a base;

a plurality of ports having interconnecting fluid passageways mounted on said base;

a plurality of piercing connectors respectively attached to said plurality of ports, each of said plurality of piercing connectors being adapted to receive and penetrate a vial;

a plurality of retainers mounted to said base and respectively located in spaced relation to said plurality of piercing connectors, each of said plurality of retainers being adapted to respectively maintain the vials in spaced relation with said plurality of piercing connectors prior to operation of the drug mixing and transfer device; and

at least one syringe attaching port having a fluid passageway interconnected with said interconnecting fluid passageways of said plurality of ports.

11. The drug mixing and transfer device of claim 10, wherein said base and said plurality of retainers are constructed out of single piece molded plastic.

12. The drug mixing and transfer device of claim 10, wherein said piercing connector further comprises:

a generally cylindrically cup shaped housing;

an annular claw attached generally annularly around the inner surface of said housing; and

a piercing cannula generally fixed axially within said housing, said cannula forming a fluid pathway through said housing that communicates with the corresponding fluid passageway of said plurality of ports.

13. The drug mixing and transfer device of claim 10, further comprising a vial mounted in each of said plurality of retainers and filled with either a liquid diluent, a liquid drug, or a lyophilized drug.