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Coated substrates employing oriented layers of mutant heme proteins and methods of making and using same

  • US 5,466,589 A
  • Filed: 09/11/1992
  • Issued: 11/14/1995
  • Est. Priority Date: 11/19/1990
  • Status: Expired due to Term
First Claim
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1. A coated substrate comprisinga substrate having at least a first portion having a surface;

  • anda plurality of mutant heme protein molecules having heme prosthetic groups and preferential binding sites, wherein said preferential binding site of each mutant heme protein molecule was provided by replacement of a surface amino acid residue and said preferential binding site is a reacted amino acid residue coupled with a functional group of said surface of said first portion, such that a coating of said mutant heme protein molecules is formed on said surface of said first portion, and the heme prosthetic groups of said coating of said surface of said first portion have the same spatial relationship with respect to to said surface of said first portion.

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