Use of IGF-1

• US 5,466,670 A
• Filed: 02/01/1994
• Issued: 11/14/1995
• Est. Priority Date: 05/19/1992
• Status: Expired due to Term

• Current Assignee: Chiron Corporation (Bayer AG)
• Original Assignee: Pharmacia AB (Pharmacia Corp.)
• Inventors: Dunger, David B., Sonksen, Peter H., Savage, Martin O.
• Primary Examiner(s): Warden, Jill
• Assistant Examiner(s): Prickril, Benet
• Application Number:
  US08/175,404
• Time in Patent Office: 651 Days
• Field of Search: 514/12
• US Class Current: 514/6.9
• CPC Class Codes: A61K 38/30 Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2 insulin-like growth factor binding protein A61K38/1754
• CPC Class Codes: A61P 3/08 for glucose homeostasis pancreatic hormones A61P5/48
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics

Abstract

The invention relates to the use of IGF-1 for the manufacture of a medicament for treatment of Type 1 diabetes mellitus. the medicament comprising a subcutaneous dose not greater than needed to achieve an IGF-1 serum level characteristic for healthy individuals i.e. a physiological replacement of serum IGF-1. This treatment would be especially valuable for the treatment of children or adolescents with Type 1 diabetes mellitus and could lead to improvements in their pubertal growth.

Claims

1. Method for treating Type 1 diabetes mellitus by subcutaneously administering to a patient suffering from Type 1 diabetes mellitus, IGF-1 in a dose effective to achieve an IGF-1 serum level of up to 400 ng/ml that is characteristic in healthy individuals.

2. The method of claim 1 wherein said patient suffering from Type I diabetes mellitus is a child, adolescent or young adult and said treating reduces the GH level.

3. The method of claim 2 wherein said treating reduces the insulin requirements of said patient.

4. The method of claim 1 wherein said treating is for improved and stabilized glycemic control in said patient as compared to not treating with said IGF-I.

5. The method of claim 1 wherein said patient suffering from Type I diabetes mellitus is a child or adolescent.

6. The method of claim 1 which comprises administering a medicament comprising said IGF-I and an insulin preparation.

7. The method of claim 1 which comprises administering a medicament containing said IGF-I by a single injection.

8. The method of claim 7 wherein a single injection is administered once or twice a day.

9. The method of claim 7 wherein a single injection is administered one to three times a week.

10. The method of claim 7 wherein a single injection is administered one to seven days a month.

11. The method of claim 7 wherein comprises administering a medicament containing said IGF-I in the form of a depot or slow release preparation.

12. The method of claim 1 wherein said IGF-I serum level characteristic in healthy individuals is about 200 ng/ml or about 400 ng/ml during puberty.

13. The method of claim 1 wherein said IGF-I is rh IGF-I.