Method and compositions for enhancing white blood cell functioning on a mucosal or cutaneous surface
First Claim
1. A method for treating or preventing a condition in a mammal caused by the presence of a disease causing agent on a mucosal surface or a cutaneous surface wherein said disease causing agent can be diminished by the actions of the white blood cells of a mammal comprising contacting the mucosal surface or the cutaneous surface of said mammal in need of said treatment or prevention with an effective amount to treat or prevent said condition of a composition comprising:
- (a) an energy source for white blood cells;
(b) a source of cations to provide a cation selected from the group consisting of sodium, potassium, magnesium, calcium and mixtures thereof; and
(c) a source of anions to provide an anion selected from the group consisting of chloride, sulfate, phosphate, bicarbonate, and mixtures thereof;
wherein the pH of said composition is from about 4 to about 10 and the osmolality of said composition is from about 140 mOsm/kg to about 2,000 mOsm/kg;
with the proviso that said mucosal surface is not the oral cavity.
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Accused Products
Abstract
The present invention relates to a method for enhancing white blood cell functioning and metabolism on a mucosal surface of a mammal. The present invention also relates to a method for treating or preventing a condition in a mammal caused by the presence of a disease-causing agent on a mucosal surface or a cutaneous surface wherein the disease-causing agent can be diminished by the actions of the white blood cells. The present invention yet also relates to a method for healing a wound of a mucosal or cutaneous surface. The present invention also relates to compositions for use in such methods.
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Citations
98 Claims
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1. A method for treating or preventing a condition in a mammal caused by the presence of a disease causing agent on a mucosal surface or a cutaneous surface wherein said disease causing agent can be diminished by the actions of the white blood cells of a mammal comprising contacting the mucosal surface or the cutaneous surface of said mammal in need of said treatment or prevention with an effective amount to treat or prevent said condition of a composition comprising:
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(a) an energy source for white blood cells; (b) a source of cations to provide a cation selected from the group consisting of sodium, potassium, magnesium, calcium and mixtures thereof; and (c) a source of anions to provide an anion selected from the group consisting of chloride, sulfate, phosphate, bicarbonate, and mixtures thereof; wherein the pH of said composition is from about 4 to about 10 and the osmolality of said composition is from about 140 mOsm/kg to about 2,000 mOsm/kg;
with the proviso that said mucosal surface is not the oral cavity. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 92)
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41. A method for healing a wound of a mucosal surface or cutaneous surface of a mammal comprising contacting the mucosal surface or the cutaneous surface of a mammal in need of said healing with a therapeutically effective amount of a composition comprising:
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(a) an energy source for white blood cells; (b) a source of cations to provide a cation selected from the group consisting of sodium, potassium, magnesium, calcium and mixtures thereof; and (c) a source of anions to provide an anion selected from the group consisting of chloride, sulfate, phosphate, bicarbonate and mixtures thereof; wherein the pH of said composition is from about 4 to about 10 and the osmolality of said composition is from about 140 mOsm/kg to about 2,000 mOsm/kg. - View Dependent Claims (42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 93)
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73. A composition comprising:
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(a) a source of cations to provide a cation selected from the group consisting of magnesium, calcium and mixtures thereof; (b) a source of anions to provide an anion selected from the group consisting of phosphate, bicarbonate and mixtures thereof; (c) a chelating agent capable of contributing to the stabilization of said composition; and (d) a cellulose ether polymer; wherein the molar ratio of said chelating agent to the total numbers of moles of said calcium cations plus said magnesium cations is such that said composition results in no greater than about a 10% by weight decrease in the calcium plus magnesium concentration in said composition after four weeks of storage at 42°
C. when the composition is formulated as an aqueous solution to have a pH of about 4 and an osmolality of about 140 mOsm/kg to about 2,000 mOsm/kg. - View Dependent Claims (74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 94)
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85. A method for treating or preventing a condition in a mammal caused by the presence of a disease causing agent on a mucosal surface or a cutaneous surface wherein said disease causing agent can be diminished by the actions of the white blood cells of a mammal comprising contacting the mucosal surface or the cutaneous surface of said mammal in need of said treatment or prevention with an effective amount to treat or prevent said condition of a composition comprising:
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(a) a source of cations to provide a cation selected from the group consisting of magnesium, calcium and mixtures thereof; (b) a source of anions to provide an anion selected from the group consisting of phosphate, bicarbonate and mixtures thereof; (c) a chelating agent capable of contributing to the stabilization of said composition; (d) a cellulose ether polymer; and (e) an energy source for white blood cells; wherein the molar ratio of said chelating agent to the total numbers of moles of said calcium cations plus said magnesium cations is such that said composition results in no greater than about a 10% by weight decrease in the calcium plus magnesium concentration in said composition and the pH of said composition is from about 4 to about 10 and the osmolality of said composition is from about 140 mOsm/kg to about 2,000 mOsm/kg. - View Dependent Claims (86, 95)
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87. A method for healing a wound of a mucosal surface or cutaneous surface of a mammal comprising contacting the mucosal surface or the cutaneous surface of a mammal in need of said healing with a therapeutically effective amount of a composition comprising:
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(a) a source of cations to provide a cation selected from the group consisting of magnesium, calcium and mixtures thereof; (b) a source of anions to provide an anion selected from the group consisting of phosphate, bicarbonate and mixtures thereof; (c) a chelating agent capable of contributing to the stabilization of said composition; (d) a cellulose ether polymer; and (e) an energy source for white blood cells; wherein the molar ratio of said chelating agent to the total numbers of moles of said calcium cations plus said magnesium cations is such that said composition results in no greater than about a 10% by weight decrease in the calcium plus magnesium concentration in said composition after four weeks of storage at 42°
C. and the pH of said composition is from about 4 to about 10 and the osmolality of said composition is from about 140 mOsm/kg to about 2,000 mOsm/kg. - View Dependent Claims (96)
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88. A method for healing a wound of a mucosal surface or cutaneous surface of a mammal comprising contacting the mucosal surface or the cutaneous surface of a mammal in need of said healing with a therapeutically effective amount of a composition comprising:
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(a) an energy source for white blood cells; (b) a source of cations to provide a cation selected from the group consisting of sodium, potassium, magnesium, calcium and mixtures thereof; (c) a source of anions to provide an anion selected from the group consisting of chloride, sulfate, phosphate, bicarbonate and mixtures thereof; and (d) acetic acid or a salt thereof; wherein the pH of said composition is from about 4 to about 10 and the osmolality of said composition is from about 140 mOsm/kg to about 2,000 mOsm/kg. - View Dependent Claims (97)
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89. A method for treating or preventing in a mammal a condition selected from the group consisting of oral viral infections, oral fungal infections, oral radiation mucositis, the effects of radiation or antidepressant induced salivary dysfunction and the effects on oral soft tissues resulting from Xerostomia, which comprises contacting the oral mucosa or gingival mucosa of a mammal in need of said treatment or prevention with an effective amount to treat or prevent said condition of a composition comprising:
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(a) an energy source for white blood cells; (b) a source of cations to provide a cation selected from the group consisting of sodium, potassium, magnesium, calcium and mixtures thereof; and (c) a source of anions to provide an anion selected from the group consisting of chloride, sulfate, phosphate, bicarbonate and mixtures thereof; wherein the pH of said composition is from about 4 to about 10 and the osmolality of said composition is from about 140 mOsm/kg to about 2,000 mOsm/kg. - View Dependent Claims (90, 91, 98)
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Specification