Devices for detection of an analyte based upon light interference
First Claim
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1. An optical assay device for detecting the presence or amount of an analyte of interest comprising:
- a substrate consisting of one or more layers having an optically active surface exhibiting a first color in response to light impinging thereon, and exhibiting a second color comprising a combination of wavelengths of light different from said first color in response to said light when said analyte is present on said surface,an anti-reflective film provided on said substrate,an attachment layer selected from the group consisting of a polymeric silane, polymeric siloxane, and a dendrimer, on said anti-reflective film and,a specific binding layer for said analyte, attached to said attachment layer.
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Abstract
Device for detecting the presence or amount of an analyte of interest, having a substrate possessing an optically active surface which exhibits a first color in response to light impinging thereon, and exhibits a second color comprising a combination of wavelengths of light different from the first color or comprising an intensity of at least one wavelength of light different from the first color, in response to the light when the analyte is present on the surface in any amount selected from 0.1 nM, 0.1 ng/ml, 50 fg, and 2×103 organisms comprising the analyte.
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Citations
47 Claims
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1. An optical assay device for detecting the presence or amount of an analyte of interest comprising:
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a substrate consisting of one or more layers having an optically active surface exhibiting a first color in response to light impinging thereon, and exhibiting a second color comprising a combination of wavelengths of light different from said first color in response to said light when said analyte is present on said surface, an anti-reflective film provided on said substrate, an attachment layer selected from the group consisting of a polymeric silane, polymeric siloxane, and a dendrimer, on said anti-reflective film and, a specific binding layer for said analyte, attached to said attachment layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 46, 47)
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13. An optical assay device for detecting the presence or amount of an analyte of interest comprising:
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a substrate consisting of one or more layers having an optically active surface exhibiting a first color in response to light impinging thereon, and exhibiting a second color comprising an intensity of at least one wavelength of light different from said first color, in response to said light when said analyte is present on said surface; an attachment layer selected from the group consisting of a polymeric silane, polymeric siloxane, and a dendrimer, on said substrate and; a specific binding layer for said analyte, attached to said attachment layer. - View Dependent Claims (45)
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Specification