Class microfiber histamine assay device
First Claim
1. In a diagnostic test device for use in an assay for histamine comprising a plurality of crushed glass microfibers which hinds histamine and which are deposited onto a carrier,the improvement which comprises that the crushed glass microfibers have been conglomerated by a binder which reduces the affinity of the conglomerated crushed glass microfibers towards interfering components in a sample while their histamine-binding capacity is substantially retained;
- said binder being a polar organic polymer having a solubility parameter sphere substantially encompassing the solubility parameters for histamine.
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Abstract
A histamine diagnostic assay device is provided in which glass microfibers treated with a polar organic polymer are deposited onto a carrier and used to selectively bind histamine in a sample. The polar organic polymer reduces the affinity of the glass microfibers for interfering components of the sample while substantially retaining the histamine-binding capacity. Preferably, the glass microfibers are provided as a conglomerate with the polar organic polymer. An agent which induces the release of histamine from cells in the sample may be included in the device.
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Citations
14 Claims
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1. In a diagnostic test device for use in an assay for histamine comprising a plurality of crushed glass microfibers which hinds histamine and which are deposited onto a carrier,
the improvement which comprises that the crushed glass microfibers have been conglomerated by a binder which reduces the affinity of the conglomerated crushed glass microfibers towards interfering components in a sample while their histamine-binding capacity is substantially retained; - said binder being a polar organic polymer having a solubility parameter sphere substantially encompassing the solubility parameters for histamine.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. In a method for preparing a diagnostic test device for use in determination of histamine, wherein crushed glass microfibers which bind histamine and are suspended in a liquid are deposited and fixed onto a carrier,
the improvement which comprises mixing the crushed glass microfibers with a binder distributed in the liquid, said binder being a polar organic polymer having a solubility parameter sphere substantially encompassing the solubility parameter for histamine; - and
drying the resulting mixture to obtain a solid conglomerate deposited and fixed onto said carrier. - View Dependent Claims (14)
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Specification