Methods for inhibiting bone loss and cartilage degradation using wortmannin and its analogs

• US 5,468,773 A
• Filed: 06/13/1994
• Issued: 11/21/1995
• Est. Priority Date: 08/25/1993
• Status: Expired due to Fees

• Current Assignee: Eli Lilly and Company
• Original Assignee: Eli Lilly and Company
• Inventors: Sato, Masahiko, Dodge, Jeffrey A.
• Primary Examiner(s): Chan, Nicky
• Application Number:
  US08/259,315
• Time in Patent Office: 526 Days
• Field of Search: 549/275, 549/457, 514/453, 514/468
• US Class Current: 514/453
• CPC Class Codes: A61K 31/365 Lactones
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 19/10 for osteoporosis
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00

Abstract

Wortmannin and certain of its analogs are inhibitors of bone loss/bone resorption and cartilage degradation.

Claims

1. A method of inhibiting bone resorption in a subject comprising administering to said subject a pharmaceutically effective dose of a compound selected from ##STR9## or a pharmaceutically acceptable salt thereof.

3. The method of claim 1 wherein said subject has or is susceptible to osteoporosis.

4. The method of claim 1 wherein the compound is administered prophylactically.

2. A method of inhibiting cartilage degradation in a subject comprising administering the said subject a pharmaceutically effective dose of a compound selected from ##STR10## or a pharmaceutically acceptable salt thereof.