System for the treatment of pathological tissue having a catheter with a pressure sensor

• US 5,470,350 A
• Filed: 03/28/1994
• Issued: 11/28/1995
• Est. Priority Date: 04/02/1993
• Status: Expired due to Fees

• Current Assignee: Siemens AG
• Original Assignee: Siemens AG
• Inventors: Buchholtz, Gerhard, Schaetzle, Ulrich
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US08/218,582
• Time in Patent Office: 610 Days
• Field of Search: 607/96, 607/97, 607/98, 607/99, 607/100, 607/101, 607/102, 607/103, 607/104, 607/105, 607/113, 128/654, 128/656, 128/658, 128/660.01, 128/660.03, 128/660.07
• US Class Current: 601/3
• CPC Class Codes: A61B 2017/00274 Prostate operation, e.g. prostatectomy, turp, bhp treatment
• CPC Class Codes: A61B 2018/00547 Prostate
• CPC Class Codes: A61B 2090/064 for measuring force, pressure or mechanical tension
• CPC Class Codes: A61B 2090/3925 ultrasonic
• CPC Class Codes: A61B 8/0833 involving detecting or locating foreign bodies or organic structures
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

A therapy system for treating pathological tissue with heating radiation includes an ultrasound locating system and a catheter introducible into the body of a patient to be treated, the catheter having at least one pressure sensor in the region of its distal end. The catheter is used to apply the heating radiation to a specified site within the patient. The pressure sensor generates signals due to interaction with the diagnostic ultrasound waves of the ultrasound locating system, and these signals are supplied to an image generating unit within the ultrasound locating system. The image generating unit calculates the position of the pressure sensor in the ultrasound image on the basis of the signals from the pressure sensor, and mixes a mark into the displayed image at the appropriate location, so that the position of the catheter is thereby identifiable.

Claims

1. A therapy apparatus for treating pathological tissue with heating radiation comprising:

a source of heating radiation, said heating radiation having an active therapeutic region with a center;

a catheter introducible into the body of a patient to be treated with said heating radiation, said catheter having a distal end and a pressure sensor disposed approximately at said distal end, said pressure sensor generating output signals corresponding to a pressure sensed by said pressure sensor; and

ultrasound locating means for generating an ultrasound image of a region to be treated by said heating radiation, said ultrasound locating means including an ultrasound locating transducer which emits diagnostic ultrasound waves and an image-generating unit to which said output signals of said pressure sensor are supplied, said output signals arising due to charging of said pressure sensor with said diagnostic ultrasound waves, and said image-generating unit including means for identifying a position of said pressure sensor in said ultrasound image on the basis of said output signals, and for mixing a mark into said ultrasound image identifying the position of said pressure sensor, and for mixing a further mark into said ultrasound image identifying a position of the center of said active therapeutic region.

2. A therapy apparatus for treating pathological tissue with heating radiation comprising:

a source of focused ultrasound therapy waves having an active therapeutic region;

a catheter introducible into the body of a patient to be treated with said focused ultrasound therapy waves, said catheter having a distal end and a pressure sensor disposed approximately at said distal end, said pressure sensor generating output signals corresponding to a pressure sensed by said pressure sensor arising due to charging of said pressure sensor with said focused ultrasound therapy waves; and

ultrasound locating means for generating an ultrasound image of a region to be treated by said focused ultrasound therapy waves, said ultrasound locating means including an ultrasound locating transducer which emits diagnostic ultrasound waves and an image-generating unit to which said output signals of said pressure sensor are supplied, said pressure sensor also generating output signals arising due to charging of said pressure sensor with said diagnostic ultrasound waves, said image-generating unit including alarm means for initiating a reaction if said output signal has a level which upwardly exceeds a limit value, and said image-generating unit including means for identifying the position of said pressure sensor in said ultrasound image on a basis of said output signals, and for mixing a mark into said ultrasound image identifying a position of said pressure sensor, and for mixing a further mark into said ultrasound image identifying the position of said active therapeutic region.

3. A therapy apparatus as claimed in claim 2 wherein said means for initiating a reaction comprises means for generating a humanly perceptible alarm signal.

4. A therapy apparatus as claimed in claim 2 wherein said means for initiating a reaction comprises means for suppressing output of said focused ultrasound therapy waves from said source of focused ultrasound therapy waves.

5. A therapy apparatus as claimed in claim 2 wherein said focused ultrasound therapy waves have an intensity, and wherein said means for initiating a reaction comprise means for lowering said intensity of said focused ultrasound therapy waves.

6. A therapy apparatus as claimed in claim 2 further comprising means for circulating a coolant through said catheter.

7. A therapy apparatus as claimed in claim 2 further comprising a temperature sensor disposed approximately at said distal end of said catheter.

8. A therapy apparatus for treating pathological tissue with heating radiation comprising:

a source of heating radiation, said heating radiation having an active therapeutic region;

a catheter adapted for introduction into the urethra of a patient to be treated with said heating radiation, said catheter having a distal end and having a first and second a pressure sensors disposed approximately at said distal end, said first and said second pressure sensors being disposed a distance from each other along said catheter, said distance adapted to correspond to the distance between the sphincter externus and the sphincter internus of said patient to be treated, said first and said second pressure sensors each generating output signals corresponding to pressure respectively sensed by said first and second pressure sensors; and

ultrasound locating means for generating an ultrasound image of a region to be treated by said heating radiation, said ultrasound locating means including an ultrasound locating transducer which emits diagnostic ultrasound waves and an image-generating unit to which said output signals of said first and said second pressure sensor are supplied, said output signals arising due to charging of said first and second pressure sensors with said diagnostic ultrasound waves, and said image-generating unit including means for identifying a position of said first and said second pressure sensors in said ultrasound image on the basis of said output signals, and for mixing respective marks into said ultrasound image identifying the positions of said first and said second pressure sensors, and for mixing a further mark into said ultrasound image identifying a position of said active therapeutic region.

9. A therapy apparatus for treating pathological tissue with heating radiation comprising:

a source of heating radiation, said heating radiation having an active therapeutic region;

a catheter adapted for introduction into the urethra of a patient to be treated with said heating radiation, said catheter having a distal end and a pressure sensor disposed approximately at said distal end, said pressure sensor generating output signals corresponding to a pressure sensed by said pressure sensor;

ultrasound locating means for generating an ultrasound image of a region to be treated by said heating radiation, said ultrasound locating means including an ultrasound locating transducer which emits diagnostic ultrasound waves and an image-generating unit to which said output signals of said pressure sensor are supplied, said output signals arising due to charging of said pressure sensor with said ultrasound diagnostic waves, and said image-generating unit including means for identifying a position of said pressure sensor in said ultrasound image on the basis of said output signals, and for mixing a mark into said ultrasound image identifying the position of said pressure sensor, and for mixing a further mark into said ultrasound image identifying a position of said active therapeutic region; and

an expandable balloon disposed at said distal end of said catheter spaced from said pressure sensor by a distance adapted to correspond to an average spacing of the inside of the bladder from the sphincter externus of a population of patients to be treated.

10. A therapy apparatus for treating pathological tissue with heating radiation comprising:

a source of heating radiation, said heating radiation having an active therapeutic region;

a catheter introducible into the body of a patient to be treated with said heating radiation, said catheter having a distal end and a pressure sensor disposed approximately at said distal end, said pressure sensor generating output signals corresponding to a pressure sensed by said pressure sensor;

ultrasound locating means for generating an ultrasound image of a region to be treated by said heating radiation, said ultrasound locating means including an ultrasound locating transducer which emits diagnostic ultrasound waves and an image-generating unit to which said output signals of said pressure sensor are supplied, said output signals arising due to charging of said pressure sensor with said diagnostic ultrasound waves, and said image-generating unit including means for identifying a position of said pressure sensor in said ultrasound image on the basis of said output signals, and for mixing a mark into said ultrasound image identifying the position of said pressure sensor, and for mixing a further mark into said ultrasound image identifying a position of said active therapeutic region; and

an acoustic marking member disposed on said catheter in a region of said pressure sensor, said acoustic marking member having an acoustic impedance adapted to deviate from the acoustic impedance of surrounding tissue when said catheter is introduced into said patient so that said marking member appears in said image generated by said ultrasound image-generating unit.

11. A therapy apparatus for treating pathological tissue with heating radiation comprising:

a source of heating radiation said heating radiation having an active therapeutic region;

a catheter introducible into the body of a patient to be treated with said heating radiation, said catheter having a distal end and two pressure sensors spaced from each other along said catheter approximately at said distal end, said pressure sensors each generating output signals corresponding to pressure respectively sensed by said pressure sensors;

ultrasound locating means for generating an ultrasound image of a region to be treated by said heating radiation, said ultrasound locating means including an ultrasound locating transducer which emits diagnostic ultrasound waves and an image-generating unit to which said output signals of said two pressure sensors are supplied, said output signals arising due to charging of each of said two pressure sensors with said diagnostic ultrasound waves, and said image-generating unit including means for identifying the respective positions of said two pressure sensors in said ultrasound image on the basis of said output signals and for mixing respective marks into said ultrasound image identifying the positions of said two pressure sensors, and for mixing a further mark into said ultrasound image identifying a position of said active therapeutic region; and

a temperature sensor disposed on said catheter between said two pressure sensors.

12. A therapy apparatus for treatment of pathological tissue in a patient with heating radiation comprising:

a source of heating radiation, said heating radiation having an active therapeutic region;

a catheter introducible into the body of a patient to be treated, said catheter having a distal end with a pressure sensor disposed approximately at said distal end, said pressure sensor generating output signals arising due to charging of said pressure sensor with pressure;

ultrasound locating means for generating an ultrasound image of a region of said patient to be treated, including an ultrasound locating transducer which generates diagnostic ultrasound waves and an image generating means, supplied with said output signals from said pressure sensor which arise due to charging of said pressure sensor with said diagnostic ultrasound waves, for identifying a position of said pressure sensor in said ultrasound image on the basis of said output signals of said pressure sensor; and

adjustment means for producing relative displacement between said region to be treated and said active therapeutic region, including control means, supplied with said output signals of said pressure sensor, for actuating said adjustment means for avoiding charging of tissue in a region surrounding said pressure sensor with said heating radiation.

13. A therapy apparatus as claimed in claim 12 wherein said image-generating means includes means for identifying a position of said pressure sensor in said ultrasound image by mixing a mark into said ultrasound image at a location corresponding to the position of said pressure sensor.

14. A therapy apparatus as claimed in claim 12 wherein said source of heating radiation comprises a source of focused ultrasound therapy waves, wherein said pressure sensor generates output signals arising due to charging of said pressure sensor with said focused ultrasound therapy waves, said output signal being supplied to said image-generating means and said image-generating means including alarm means for initiating a reaction if said output signals have a level which upwardly exceeds a limit value.

15. A therapy apparatus as claimed in claim 14 wherein said means for initiating a reaction comprises means for generating a humanly perceptible alarm signal.

16. A therapy apparatus as claimed in claim 14 wherein said means for initiating a reaction comprises means for suppressing output of said focused ultrasound therapy waves from said source of focused ultrasound therapy waves.

17. A therapy apparatus as claimed in claim 14 wherein said focused ultrasound therapy waves have an intensity, and wherein said means for initiating a reaction comprise means for lowering said intensity of said focused ultrasound therapy waves.