Aqueous maltodextrin and cellulosic polymer film coatings
First Claim
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1. A method of coating substrates from the group consisting of pharmaceutical tablets, food and confectionery forms, and agricultural seeds, with a protective film comprising the steps of mixing a film former, the film former including a film forming amount of cellulosic polymer and a film forming amount of maltodextrin, and a plasticizer into water to form an aqueous coating suspension, the cellulosic polymer being in a range of greater than 5% to about 90% by weight of the non-water ingredients of the aqueous coating suspension, the maltodextrin being in a range of about 5% to about 78.5% by weight of the non-water ingredients of the aqueous coating suspension, and the plasticizer being in a range of about 2.5% to about 20% by weight of the non-water ingredients of the aqueous coating suspension, applying an effective amount of said coating suspension onto said substrates to form a film coating of the film former on said substrates, and drying the film coating on said substrates.
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Abstract
A method of coating substrates such as pharmaceutical tablets, food and confectionery forms, agricultural seeds and the like, with a protective film comprises the steps of mixing a cellulosic polymer, maltodextrin, and a plasticizer into water to form an aqueous coating suspension, spraying an effective amount of said coating suspension onto said substrates to form a film coating on said substrates, and drying the film coating on said substrates. Optionally, a detackifier, a secondary film former, a flow aid, and/or a colorant may be dispersed into the coating suspension before applying the coating suspension to the substrates. A dry powder edible film coating composition for use in pharmaceuticals, food and confectionery forms, agricultural seeds, and the like, comprises a dry mixture of a cellulosic polymer, maltodextrin, and a plasticizer. Optionally, the dry coating composition may include a detackifier, a secondary film former, a flow aid, and/or a colorant.
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62 Claims
- 1. A method of coating substrates from the group consisting of pharmaceutical tablets, food and confectionery forms, and agricultural seeds, with a protective film comprising the steps of mixing a film former, the film former including a film forming amount of cellulosic polymer and a film forming amount of maltodextrin, and a plasticizer into water to form an aqueous coating suspension, the cellulosic polymer being in a range of greater than 5% to about 90% by weight of the non-water ingredients of the aqueous coating suspension, the maltodextrin being in a range of about 5% to about 78.5% by weight of the non-water ingredients of the aqueous coating suspension, and the plasticizer being in a range of about 2.5% to about 20% by weight of the non-water ingredients of the aqueous coating suspension, applying an effective amount of said coating suspension onto said substrates to form a film coating of the film former on said substrates, and drying the film coating on said substrates.
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7. A method of making a dry edible film coating composition for use in coating pharmaceutical tablets, food and confectionery forms, and agricultural seeds, with a protective film, comprising the steps of
mixing a film former, the film former including a film forming amount of cellulosic polymer and a film forming amount of maltodextrin, and a plasticizer into a solvent to form a coating dispersion, the cellulosic polymer being in a range of greater than 5% to about 90% by weight of non-solvent ingredients of the coating dispersion, the maltodextrin being in a range of about 5% to about 78.5% by weight of non-solvent ingredients of the coating dispersion, and the plasticizer being in a range of about 2.5% to about 20% by weight of non-solvent ingredients for the coating dispersion, evaporating the solvent in the coating dispersion to obtain the dry edible film coating composition, further including mixing a detackifier, a secondary film former, a flow aid, and a colorant into the solvent when forming the coating dispersion.
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21. The method of making a coating dispersion for coating substrates from the group consisting of pharmaceutical tablets, food and confectionery forms, and agricultural seeds, comprising the steps of
mixing a film former, the film former including a film forming amount of cellulosic polymer and a film forming amount of maltodextrin, and a plasticizer into water to form an aqueous coating dispersion, the cellulosic polymer being in a range of greater than 5% to about 90% by weight of non-water ingredients of the coating dispersion, the maltodextrin being in a range of about 5% to about 78.5% by weight of non-water ingredients of the coating dispersion, and the plasticizer being in a range of about 2.5% to about 20% by weight of non-water ingredients of the coating dispersion, further including dispersing a detackifier, a secondary film former, a flow aid, and a colorant into the aqueous coating dispersion.
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24. An aqueous coating dispersion for coating substrates from the group consisting of pharmaceutical tablets, food and confectionery forms, and agricultural seeds, comprising a mixture of
a film former, the film former including a film forming amount of cellulosic polymer and a film forming amount of maltodextrin, a plasticizer, and water, the cellulosic polymer being in a range of greater than 5% to about 90% by weight of the non-water ingredients of the aqueous coating suspension, the maltodextrin being in a range of about 5% to about 78.5% by weight of the non-water ingredients of the aqueous coating suspension, and the plasticizer being in a range of about 2.5% to about 20% by weight of the non-water ingredients of the aqueous coating suspension, further including a detackifier, a secondary film former, a flow aid, and a colorant.
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31. A method of coating substrates from the group consisting of pharmaceutical tablets, food and confectionery forms, and agricultural seeds, with a protective film comprising the steps of
mixing a film former, the film former including a film forming amount of cellulosic polymer and a film forming amount of maltodextrin, a plasticizer, a detackifier, a secondary film former, a flow aid, and a colorant into water to form an aqueous coating suspension, the cellulosic polymer being in a range of about 30% to 70% by weight of the non-water ingredients of the aqueous coating suspension, the maltodextrin being in a range of about 20% to 50% by weight of the non-water ingredients of the aqueous coating suspension, the plasticizer being in a range of about 5% to 10% by weight of the non-water ingredients of the aqueous coating suspension, the detackifier being in a range of greater than 0% to about 10% by weight of the non-water ingredients of the aqueous coating suspension, the secondary film former being in a range of greater than 0% to 5% by weight of the non-water ingredients of the aqueous coating suspension, the flow aid being in a range of greater than 0% to about 10% by weight of the non-water ingredients of the aqueous coating suspension, and the colorant being in a range of greater than 0% to about 20% by weight of the non-water ingredients of the aqueous coating suspension, the maltodextrin having an average molecular weight less than about 27,000, the cellulosic polymer being selected from the group consisting of methylcellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, hydroxyethyl cellulose, and carboxymethylcellulose, the plasticizer being selected from the group consisting of polyethylene glycol, triacetin, propylene glycol, acetyltriethyl citrate, triethyl citrate, and glycerin, the detackifier being selected from the group consisting of lecithin and stearic acid, the secondary film former being selected from the group consisting of sodium alginate, propylene glycol alginate, and polyvinylpyrrolidone, the flow aid being selected from the group consisting of talc, fumed silica, bentonite, edible hydrogenated vegetable oils, and hydrogenated vegetable oil and waxes, the colorant being selected from the group consisting of FD& - C lakes, D&
C lakes, titanium dioxide and dyes, andspraying an effective amount of said coating suspension onto said substrates to form a film coating of the film former on said substrates, and drying the film coating on said substrates.
- C lakes, D&
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32. A method of coating substrates from the group consisting of pharmaceutical tablets, food and confectionery forms, and agricultural seeds, with a protective film comprising the steps of
mixing a film former, the film former including a film forming amount of cellulosic polymer and a film forming amount of maltodextrin, a plasticizer, a detackifier, a secondary film former, a flow aid, and a colorant into water to form an aqueous coating suspension, the cellulosic polymer being in a range of greater than 5% to about 90% by weight of the non-water ingredients of the aqueous coating suspension, the maltodextrin being in a range of about 5% to 78.5% by weight of the non-water ingredients of the aqueous coating suspension, the plasticizer being in a range of about 2.5% to 20% by weight of the non-water ingredients of the aqueous coating suspension, the detackifier being in a range of greater than 0% to about 15% by weight of the non-water ingredients of the aqueous coating suspension, the secondary film former being in a range of greater than 0% to about 10% by weight of the non-water ingredients of the aqueous coating suspension, the flow aid being in a range of greater than 0% to about 20% by weight of the non-water ingredients of the aqueous coating suspension, and the colorant being in a range of greater than 0% to about 30% by weight of the non-water ingredients of the aqueous coating suspension, the maltodextrin having an average molecular weight of less than about 27,000, the cellulosic polymer being selected from the group consisting of methylcellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, hydroxyethyl cellulose, and carboxymethylcellulose, the plasticizer being selected from the group consisting of polyethylene glycol, triacetin, propylene glycol, acetyltriethyl citrate, triethyl citrate, and glycerin, the detackifier being selected from the group consisting of lecithin and stearic acid, the secondary film former being selected from the group consisting of sodium alginate, propylene glycol alginate, and polyvinylpyrrolidone, the flow aid being selected from the group consisting of talc, fumed silica, bentonite, edible hydrogenated vegetable oils, and hydrogenated vegetable oil and waxes, the colorant being selected from the group consisting of FD& - C lakes, D&
C lakes, titanium dioxide and dyes andspraying an effective amount of said coating suspension onto said substrates to from a film coating of the film former on said substrates, and drying the film coating on said substrates.
- C lakes, D&
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37. A method of coating substrates from the group consisting of pharmaceutical tablets, food and confectionery forms, and agricultural seeds, with a protective film comprising the steps of forming an aqueous coating suspension consisting essentially of cellulosic polymer, maltodextrin, plasticizer, and water, the cellulosic polymer being in a range of greater than 5% to about 90% by weight of the non-water ingredients of the aqueous coating suspension, the maltodextrin being in a range of about 5% to about 78.5% by weight of the non-water ingredients of the aqueous coating suspension, and the plasticizer being in a range of about 2.5% to about 20% by weight of the non-water ingredients of the aqueous coating suspension, spraying an effective amount of said coating suspension onto said substrates to form a film coating of the film former on said substrates, and drying the film coating on said substrates.
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40. A method of making a dry edible film coating composition for use in coating pharmaceutical tablets, food and confectionery forms, and agricultural seeds, with a protecting film, comprising the steps of
mixing a film former, the film former including a film forming amount of cellulosic polymer and a film forming amount of maltodextrin, to form a cellulosic-maltodextrin polymer mix, and adding a plasticizer to the cellulosic polymer-maltodextrin mix and mixing until the combined mix is blended to form the dry edible film coating composition, the cellulosic polymer being in a range of greater than 5% to about 90% by weight of the dry edible film coating composition, the maltodextrin being in a range of about 5% to about 78.5% by weight of the dry edible film coating composition, and the plasticizer being in a range of about 2.5% to about 20% by weight of the dry edible film coating composition, further including adding a secondary film former to the mix and mixing until the combined mix is blended to form the dry edible film coating composition.
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49. A method of making a dry edible film coating composition for use in coating pharmaceutical tablets, food and confectionery forms, and agricultural seeds, with a protecting film, comprising the steps of
mixing a film former, the film former including a film forming amount of cellulosic polymer and a film forming amount of maltodextrin, to form a cellulosic-maltodextrin polymer mix, and adding a plasticizer to the cellulosic polymer-maltodextrin mix and mixing until the combined mix is blended to form the dry edible film coating composition, the cellulosic polymer being in a range of greater than 5% to about 90% by weight of the dry edible film coating composition, the maltodextrin being in a range of about 5% to about 78.5% by weight of the dry edible film coating composition, and the plasticizer being in a range of about 2.5% to about 20% by weight of the dry edible film coating composition, further including adding a detackifier to the mix and mixing until the combined mix is blended to form the dry edible film coating composition, wherein the detackifier is lecithin or stearic acid.
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53. A dry powder edible film coating composition for use in coating pharmaceuticals, food, confectionery forms, and agricultural seeds, comprising a dry mixture of
a film former, the film former including a film forming amount of cellulosic polymer and a film forming amount of maltodextrin, the cellulosic polymer being greater than 5% to about 90% by weight of the coating composition, the maltodextrin being about 5% to about 78.5% by weight of the coating composition, and a plasticizer, the plasticizer being about 2.5% to about 20% by weight of the composition, further including a secondary film former.
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54. A dry powder edible film coating composition for use in coating pharmaceuticals, food, confectionery forms, and agricultural seeds, comprising a dry mixture of
a film former, the film former including a film forming amount of cellulosic polymer and a film forming amount of maltodextrin, the cellulosic polymer being greater than 5% to about 90% by weight of the coating composition, the maltodextrin being about 5% to about 78.5% by weight of the coating composition, and a plasticizer, the plasticizer being about 2.5% to about 20% by weight of the composition, further including a colorant, wherein the colorants are in a range of 0% to 20% by weight of the composition.
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55. A dry powder edible film coating composition for use in coating pharmaceuticals, food, confectionery forms, and agricultural seeds, comprising a dry mixture of
a film former, the film former including a film forming amount of cellulosic polymer and a film forming amount of maltodextrin, the cellulosic polymer being greater than 5% to about 90% by weight of the coating composition, the maltodextrin being about 5% to about 78.5% by weight of the coating composition, and a plasticizer, the plasticizer being about 2.5% to about 20% by weight of the composition, further including a colorant, wherein said colorants are in a range of 0% to 30% by weight of the composition.
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56. A dry powder edible film coating composition for use in coating pharmaceuticals, food, confectionery forms, and agricultural seeds, comprising a dry mixture of
a film former, the film former including a film forming amount of cellulosic polymer and a film forming amount of maltodextrin, the cellulosic polymer being greater than 5% to about 90% by weight of the coating composition, the maltodextrin being about 5% to about 78.5% by weight of the coating composition, and a plasticizer, the plasticizer being about 2.5% to about 20% by weight of the composition, further including a colorant, wherein said colorants are FD& - C lakes, D&
C lakes, titanium dioxide or dyes.
- C lakes, D&
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59. A dry powder edible film coating composition for use in coating pharmaceuticals, food, confectionery forms, and agricultural seeds, comprising a dry mixture of
a film former, the film former including a film forming amount of cellulosic polymer and a film forming amount of maltodextrin, the cellulosic polymer being greater than 5% to about 90% by weight of the coating composition, the maltodextrin being about 5% to about 78.5% by weight of the coating composition, and a plasticizer, the plasticizer being about 2.5% to about 20% by weight of the composition, further including a detackifier, wherein the detackifier is lecithin or stearic acid.
Specification
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Current AssigneeBPSI Holdings Incorporated
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Original AssigneeBerwind Pharmaceutical Services, Inc. (BPSI Holdings, LLC)
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InventorsKunkle, Diane C., Saraceni, Kathleen, Steffenino, Rita M., Grillo, Susan M.
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Primary Examiner(s)Page, Thurman K.
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Assistant Examiner(s)SPEAR, JAMES M
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Application NumberUS07/991,477Time in Patent Office1,078 DaysField of Search424/459, 424/461, 424/463, 424/474, 424/475, 424/479, 424/480, 424/490US Class Current424/479CPC Class CodesA01C 1/06 Coating or dressing seedA23B 9/14 Coating with a protective l...A23G 2200/06 containing beet sugar or ca...A23G 3/343 Products for covering, coat...A23L 25/25 coated with a layerA23L 27/72 EncapsulationA23L 7/122 Coated, filled, multilayere...A23P 20/105 Coating with compositions c...A23P 20/12 Apparatus or processes for ...A61K 9/286 Polysaccharides, e.g. gums;...A61K 9/2866 Cellulose; Cellulose deriva...C08L 2666/02 Organic macromolecular comp...C09D 101/284 with hydroxylated hydrocarb...C09D 103/02 Starch; Degradation product...
