Medicinal substance for topical application

• US 5,470,585 A
• Filed: 04/12/1995
• Issued: 11/28/1995
• Est. Priority Date: 01/27/1989
• Status: Expired due to Term

• Current Assignee: Tyco Healthcare Group LP (Medtronic Plc)
• Original Assignee: Giltech Limited
• Inventors: Gilchrist, Thomas
• Primary Examiner(s): Robinson, Allen J.
• Assistant Examiner(s): Pak, John D.
• Application Number:
  US08/421,005
• Time in Patent Office: 230 Days
• Field of Search: 424/604, 424/409, 424/411, 424/417, 424/421, 424/443, 424/444, 424/445, 424/446, 424/447, 424/449, 424/489, 424/618, 424/619, 604/1, 604/2, 604/3, 604/304, 604/305, 604/307, 604/308, 604/890.1
• US Class Current: 424/604
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/08 containing solids as carriers or diluents
• CPC Class Codes: A01N 25/12 Powders or granules A01N25/26 takes precedence
• CPC Class Codes: A01N 25/34 Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 33/38 Silver; Compounds thereof
• CPC Class Codes: A61L 15/18 containing inorganic materials
• CPC Class Codes: A61L 15/46 Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence

Abstract

A medicinal substance for topical application is disclosed. The substance comprises a water-soluble glass containing silver or a silver compound. Typically, the glass comprises phosphorus pentoxide and contains silver oxide. The substance may be used for the treatment of wounds, catheter and tubing entry points, stoma sites and body passage entrances where bacterial growth and migration are rife. The glass may be in the form of a powder, granules, woven into a dressing form, a sinter shaped in a particular way or used as filler in polymers for surface release.

Claims

1. A medicinal substance capable of retarding bacterial growth at a surface of a body comprising a water-soluble glass comprising phosphorus pentoxide as a glass-forming substance, said glass containing silver orthophosphate and means to maintain the substance in contact with a surface of a body.

2. A medicinal substance according to claim 1, wherein the water-soluble glass is in the form of a powder.

3. A medicinal substance according to claim 1, wherein the water-soluble glass is in the form of fibres woven into a dressing.

4. A medicinal substance according to claim 1, further comprising a polymer in which the glass is used as a filler for surface release.

5. A medicinal substance according to claim 1, wherein the water-soluble glass further comprises sodium oxide and calcium oxide.

6. A medicinal substance, according to claim 1 or claim 5, in which said silver orthophosphate is incorporated in said glass at a glass forming temperature.

7. The method of retarding bacterial growth at the surface of a body, said surface being accessed by a body fluid, said method comprising applying a water-soluble glass to the surface, said glass comprising phosphorus pentoxide as a glass-forming substance, and said glass being impregnated with silver orthophosphate as a source of silver ions and maintaining the glass in contact with the surface, so that a controlled release of an effective amount of silver ions is obtained on dissolution of the glass in said body fluid.