Filtration device useable for removal of leukocytes and other blood components

• US 5,472,605 A
• Filed: 03/10/1994
• Issued: 12/05/1995
• Est. Priority Date: 03/10/1994
• Status: Expired due to Term

• Current Assignee: Haemonetics Puerto Rico LLC (Gvs S.P.A.)
• Original Assignee: HemaSure, Inc.
• Inventors: Zuk, Peter Jr.
• Primary Examiner(s): Kim, John
• Application Number:
  US08/209,523
• Time in Patent Office: 635 Days
• Field of Search: 210/188, 210/232, 210/433.1, 210/436, 210/451, 210/472, 422/101, 604/252, 604/324, 604/405, 604/406
• US Class Current: 210/436
• CPC Class Codes: A61M 1/3627 Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
• CPC Class Codes: A61M 1/3633 Blood component filters, e.g. leukocyte filters
• CPC Class Codes: A61M 1/3643 Priming, rinsing before or after use
• CPC Class Codes: A61M 1/3652 using gas, e.g. air
• CPC Class Codes: A61M 2202/005 residue retained by the filter due to size
• CPC Class Codes: A61M 2202/0439 White blood cells; Leucocytes
• CPC Class Codes: A61M 2205/7527 liquophilic, hydrophilic
• CPC Class Codes: A61M 2205/7536 allowing gas passage, but preventing liquid passage, e.g. liquophobic, hydrophobic, water-repellent membranes
• CPC Class Codes: B01D 19/0031 by filtration
• CPC Class Codes: B01D 36/001 Filters in combination with devices for the removal of gas, air purge systems
• CPC Class Codes: B01D 46/0012 In-line filters
• CPC Class Codes: B01D 61/18 Apparatus therefor
• CPC Class Codes: B01D 61/20 Accessories; Auxiliary operations
• CPC Class Codes: B01D 63/087 Single membrane modules

Abstract

A liquid filtration device useable for removing leukocytes from blood contains a first chamber which is in fluid flow relationship with a second chamber. Filtration elements separate the first chamber from the second chamber so that liquid flowing from the first chamber is filtered thereby prior to entry into the second chamber. A passage leads from the second chamber into the first chamber and a hydrophobic filter may be used to prevent liquid from the first chamber from flowing through the passage into the second chamber while allowing air to flow therethrough. An outlet is located in the second chamber, preferably at the bottom thereof. A second outlet may be located within the second chamber and may be placed in fluid flow relationship therewith by a conduit or the like.

Claims

1. A liquid filtration device comprising:

a first chamber having an inlet for receiving unfiltered liquid and being capable of collecting the unfiltered liquid therein;

a second chamber capable of collecting filtered liquid therein, said second chamber being in fluid flow relationship with the first chamber;

means for filtering liquid within the first chamber prior to flowing into the second chamber;

a passage leading from the second chamber into the first chamber for venting air therebetween;

means for preventing liquid within the first chamber from flowing through the passage into said second chamber; and

a first outlet in the second chamber.

2. The filtration device of claim 1 further comprising a second outlet in the second chamber, said second outlet being located above said first outlet;

and a hydrophilic filter disposed over said second outlet, said hydrophilic filter preventing air from flowing through said second outlet when said hydrophilic filter is wet.

3. The filtration device of claim 2 further comprising means for placing the first outlet in fluid flow relationship with the second outlet.

4. The filtration device of claim 3 wherein the means for placing the first outlet in fluid flow relationship with the second outlet comprises a conduit.

6. The filtration device of claim 4 further comprising tubing connected to said conduit for allowing filtered fluid to flow into a fluid collecting means.

7. The filtration device of claim 1 or 2 wherein said means for preventing unfiltered liquid within the first chamber from flowing through the passage into the second chamber comprises a hydrophobic filter.

8. The filtration device of claim 7 wherein said means for filtering fluid within the first chamber comprises at least one filtration element.

9. The filtration device of claim 8 wherein said at least one filtration element comprise a plurality of leukocyte removing elements.

10. The filtration device of claim 8 further comprising means for venting unfiltered fluid.

11. The filtration device of claim 10 wherein said venting means comprises an automatic in-line vent filter.

12. The filtration device of claim 11 wherein said automatic in-line vent filter is placed in fluid flow relationship with said first chamber.

13. The filtration device of claim 12 further comprising a liquid supply placed in fluid flow relationship with said automatic in-line vent filter.

14. The filtration device of claim 8 wherein said first chamber and second chamber are located within a housing formed by a first section and second section.

15. The filtration device of claim 14 wherein said at least one filtration element is located between said first section and second section, said at least one filtration element extending within an interior of said housing forming a barrier dividing said interior of the housing into said first and second chambers.

16. The filtration device of claim 15 wherein said at least one filtration element forms an interior wall within said housing.

17. The filtration device of claim 16 wherein edges of said at least one filtration element are oriented between the first section and second section.

18. The filtration device of claim 17 wherein said passage extends through said at least one filtration element.

19. The filtration device of claim 18 wherein said passage comprises a tube affixed to said second section.

20. The filtration device of claim 19 further comprising means for preventing unfiltered fluid from entering the second chamber by flowing between the tube and said at least one filtration element.

21. The filtration device of claim 20 wherein said preventing means comprises one or more flanged washers.

22. The filtration device of claim 20 wherein the edges of said at least one filtration element are sealed to said second section using at least one flanged ring.

23. The filtration device of claim 20 wherein when the edges of said at least one filtration element are heat sealed using a thermoplastic film between layers of edges of more than one filtration element.

24. The filtration device of claim 20 wherein said tube comprises a lip which contacts said at least one filtration element.

25. The filtration device of claim 24 wherein said means for preventing unfiltered fluid from entering the second chamber comprises a washer wherein said at least one filtration element is located between said lip and said washer mounted on said tube.

26. The filtration device of claim 25 wherein said hydrophobic filter is sealed to an opening of said tube.

27. The filtration device of claim 26 wherein said hydrophilic filter is sealed to said second section at said second outlet therein.

5. The filtration device of claim 5 wherein said conduit is integrally formed to a housing defining at least one of said chambers.

28. A filtration device for use in filtering blood comprising:

a housing;

a second chamber and a first chamber each within said housing wherein said first and second chambers are separated by a plurality of leukocyte removing elements;

a passage leading from the first chamber into the second chamber;

a hydrophobic filter disposed at one end of said passage for preventing blood within the first chamber from flowing through the passage into the second chamber;

a first outlet in said second chamber;

a second outlet in said second chamber, said first outlet being located below said second outlet;

a hydrophilic filter disposed over said second outlet for preventing air from flowing through said second outlet when said hydrophilic filter is wet; and

means for placing said first outlet in fluid flow relationship with said second outlet.

29. The filtration device of claim 28 wherein said means for placing said first outlet in fluid flow relationship with said second outlet comprises a conduit.

30. The filtration device of claim 29 wherein said conduit is integrally formed with said housing.