Brush-tipped catheter for ultrasound imaging

• US 5,474,075 A
• Filed: 11/24/1993
• Issued: 12/12/1995
• Est. Priority Date: 11/24/1993
• Status: Expired due to Fees

• Current Assignee: Thomas Jefferson University (Main Line Health System)
• Original Assignee: Thomas Jefferson University (Main Line Health System)
• Inventors: Goldberg, Barry B., Liu, Ji-Bin, Steiner, Robert M.
• Primary Examiner(s): JAWORSKI, FRANCIS J
• Application Number:
  US08/157,640
• Time in Patent Office: 748 Days
• Field of Search: 128/600.03, 128/662.06, 128/662.03, 128/756
• US Class Current: 600/463
• CPC Class Codes: A61B 10/02 Instruments for taking cell samples or for biopsy A61B10/0038 and A61B10/0045 take precedence; needle locating or guiding means A61B17/3403; samplers for enzymology or microbiology C12M1/26; sampling or preparing biological specimens G01N33/48
• CPC Class Codes: A61B 2010/0216 Sampling brushes
• CPC Class Codes: A61B 2017/22072 with an instrument channel, e.g. for replacing one instrument by the other
• CPC Class Codes: A61B 2017/320012 Brushes
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/445 Details of catheter construction
• CPC Class Codes: A61B 8/4461 Features of the scanning mechanism, e.g. for moving the transducer within the housing of the probe

Abstract

Miniature catheter-based ultrasound transducers are used to image peritracheal or bronchial structures including masses, lymph nodes, and vessels. Most preferably, a 6.2 French catheter containing either a 12.5 or 20 MHz ultrasound transducer coupled with an ultrasound unit is passed through the working channel of a flexible bronchoscope and directed to the region of interest. Patients with pulmonary masses detected by X-ray or computed tomography were studied and it was found that characteristic ultrasound patterns of masses, lymph nodes and blood vessels could be distinguished. Thus, catheter-based ultrasound transducers are useful to evaluate a variety of bronchopulmonary abnormalities. This approach was found to be valuable in the selection of the appropriate site for biopsy. In accordance with the present invention, an improved ultrasound catheter that incorporates a biopsy brush is therefore disclosed.

Claims

1. An ultrasonic catheter assembly comprising a catheter sheath and an ultrasound transducer disposed within the catheter sheath, wherein a non-inflatable tool is affixed to and extends radially beyond an exterior surface of the catheter sheath near a distal end of the catheter sheath at a point proximal of the distal end.

2. The ultrasonic catheter assembly of claim 1 wherein the tool comprises a plurality of bristles extending radially from a distal end of the catheter sheath.

3. The ultrasonic catheter assembly of claim 2 wherein the bristles extend radially for a distance of about 1 mm.

4. The ultrasonic catheter assembly of claim 2, wherein the bristles extend along an axial length of the catheter sheath for about 8 mm.

5. The ultrasonic catheter assembly of claim 2 wherein the distal end of the catheter sheath is tapered.

6. The ultrasonic catheter assembly of claim 2, wherein the bristles are all of substantially equal length.

7. The ultrasonic catheter assembly of claim 1, wherein the catheter has a diameter between 3.5-6.2 French.

8. A method of determining the location of a lesion in a subject'"'"'s tracheobronchial tree and obtaining sample tissue from the lesion in a single procedure comprising the steps of:

introducing a catheter sheath containing an ultrasound transducer into the tracheobronchial tree;

activating the ultrasound transducer to produce an ultrasound image;

reviewing the ultrasound image to determine if a lesion exists;

determining the position of the lesion;

extending a biopsy tool for obtaining a tissue sample from within the sheath; and

performing a biopsy while simultaneously imaging the lesion.

9. The method of claim 8, further comprising the step of analyzing the ultrasound image to characterize the lesion.

10. The method of claim 8, wherein the step of performing a biopsy comprises the step of manipulating a brush attached to the end of the catheter.

11. The method of claim 8, wherein the step of introducing the catheter comprises passing the catheter through biopsy port of a fiberoptic bronchoscope.

12. The method of claim 8, wherein the step of performing a biopsy comprises inserting a biopsy needle into the catheter sheath.