×

Delivery system comprising means for controlling internal pressure

  • US 5,474,785 A
  • Filed: 07/15/1993
  • Issued: 12/12/1995
  • Est. Priority Date: 01/24/1990
  • Status: Expired due to Term
First Claim
Patent Images

1. An improved delivery system for administering a beneficial agent to an environment of use, the delivery system comprising:

  • i) a wall that surrounds a lumen, the wall comprising in at least a part a semipermeable composition,ii) a thermo-responsive composition in the lumen that forms a dispensable formulation at the temperature of the environment of use,iii) a beneficial agent mixed with the thermo-responsive composition,iv) an expandable driving member in the lumen for displacing the thermo-responsive composition from the delivery system, andv) an exit opening in the wall that communicates with the lumen;

    wherein, the improvement comprises;

    a) a viscosity-inducing amount of an inert viscosity-inducing agent in the thermo-responsive composition for increasing the viscosity of the thermo-responsive composition, andb) a pressure-inducing exit member in the exit opening in the wall for increasing the pressure inside the lumen, the exit member having from 1 to exit ports or passageways;

    wherein the delivery system when in operation develops an internal pressure such that the pressure differential generated by the thermo-responsive composition and the exit member is greater than 1.5 psi.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×