System and method to monitor gastrointestinal Helicobacter pylori infection

• US 5,477,854 A
• Filed: 09/16/1993
• Issued: 12/26/1995
• Est. Priority Date: 09/16/1993
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Synectics Medical, Inc.
• Inventors: Essen-Moller, Anders
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): NASSER, ROBERT L
• Application Number:
  US08/121,468
• Time in Patent Office: 831 Days
• Field of Search: 204/403, 204/406-408, 204/412, 204/416, 128/635, 128/642, 128/644
• US Class Current: 600/350
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/42 Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems A61B1/00, A61B5/4857, A61B5/486, A61B5/4866, A61B5/4869 take precedence

Abstract

A system and a method for monitoring intragastrointestinal concentrations of ammonium during prolonged periods is presented, as an indicator of the presence and activity of an intragastrointestinal Helicobacter Pylori ("HP") infection. Ambulatory monitoring is possible. This system and method may be used in the evaluation of treatments for HP infection in the patient.

Claims

1. A method for monitoring ammonium and for diagnosing the effect of a treatment for helicobacter pylori infection comprising the steps of:

(a) attaching a gastrointestinal ammonium sensing catheter to an electronic recorder,

inserting the gastrointestinal ammonium sensing catheter into a gastrointestinal position,

recording in RAM memory in the recorder periodically during a monitoring period, a plurality of ammonium concentration readings from the gastrointestinal ammonium sensing catheter,

(d) uploading the recorded ammonium concentration readings to an electronic computer or printer,

(e) presenting graphically the recorded ammonium concentration readings,

(f) exposing the patient to a treatment for Helicobacter Pylori infection while recording the ammonium concentration readings,

(g) correlating the recorded ammonium concentration readings with any indicated effect of the treatment on any Helicobacter Pylori infection, and

(h) diagnosing a successful treatment for Helicobacter Pylori infection when the ammonium concentration readings fall and stay down, and diagnosing a failed treatment for Helicobacter Pylori infection when the ammonium concentration readings only temporarily fall, and diagnosing a failed treatment for Helicobacter Pylori infection when the ammonium concentration readings do not fall.

2. A method of monitoring ammonium and for diagnosing the effect of a treatment for Helicobacter pylori infection comprising the steps of:

(a) attaching a gastrointestinal ammonium sensing catheter to an electronic recorder,

(b) calibrating the recorder using a reference Ag/AgCl catheter,

(c) inserting the gastrointestinal ammonium sensing catheter into a gastrointestinal position,

(d) recording in RAM memory in the recorder, periodically during a monitoring, period, a plurality of ammonium concentration readings from the gastrointestinal ammonium sensing catheter,

(e) uploading the recorded ammonium concentration readings to an electronic computer or printer,

(f) presenting graphically the recorded ammonium concentration readings,

(g) exposing the patient to a treatment for Helicobacter Pylori infection while recording the ammonium concentration readings,

(h) correlating the recorded ammonium concentration readings with any indicated effect of the treatment on any Helicobacter Pylori infection, and

(i) diagnosing a successful treatment for Helicobacter Pylori infection when the ammonium concentration readings fall and stay down, and diagnosing a failed treatment for Helicobacter Pylori infection when the ammonium concentration readings only temporarily fall, and diagnosing a failed treatment for Helicobacter Pylori infection when the ammonium concentration readings do not fall.