Ergoline derivatives of 1-propinylamine, a process for the manufacture thereof and the use thereof for medicaments

• US 5,480,885 A
• Filed: 12/02/1993
• Issued: 01/02/1996
• Est. Priority Date: 07/01/1991
• Status: Expired due to Term

• Current Assignee: LEK, tovarna farmacevtskih in kemicnih izdelkov DD
• Original Assignee: LEK, tovarna farmacevtskih in kemicnih izdelkov DD
• Inventors: Rucman, Rudolf, Ocvirk, Magdalena, Lavric, Bogomila, Bole-Vunduk, Breda, Krisch, Igor
• Primary Examiner(s): Lovering, Richard D.
• Assistant Examiner(s): SCALZO, CATHERINE KILBY
• Application Number:
  US08/160,271
• Time in Patent Office: 761 Days
• Field of Search: 546/67, 546/69, 514/288
• US Class Current: 514/288
• CPC Class Codes: C07D 457/02 with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
• CPC Class Codes: C07D 457/06 Lysergic acid amides

Abstract

A method of treating psychosis including administering an antipsychotically effective amount of an ergolinyl derivative of 2-propinylamine of the formula I ##STR1## wherein, R₁, R₂, and R₃ independently represent a hydrogen atom or a straight-chain or branched-chain C₁ -C₆ alkyl group, X represents a hydrogen or a halogen atom, Z represents a carbonyl or methylene group, and C₉ - - - -C₁₀ represents a single or a double, diastereomeric forms, racemates and acid addition salts thereof.

Claims

1. A method of treating psychosis in a patient in a need of such treatment comprising administering to said patient, antipsychotically effective amount of an ergolinyl derivative of 2-propinylamine of the formula I ##STR7## wherein, R₁, R₂ and R₃ independently represent a hydrogen atom or a straight-chain or branched-chain C₁ -C₆ alkyl group,

X represents a hydrogen or a halogen atom,

Z represents a carbonyl or methylene group and

C₉ . . . C₁₀ represents a single or a double bond, diastereomeric forms, racemates and acid addition salts thereof.

2. The method of claim 1 wherein said derivative 5 is 2-Bromo-9,10-didehydro-N-methyl-N-(2'"'"'-propinyl)-6-methylergoline8β

-carboxamide, or acid addition salt thereof.

3. The method of claim 1 wherein said derivative is 8β

-Methyl-N-methyl-N-(2'"'"'propinyl)-6-methylergoline, or acid addition salt thereof.