Medical investigation system and related method

• US 5,482,041 A
• Filed: 04/25/1994
• Issued: 01/09/1996
• Est. Priority Date: 06/05/1992
• Status: Expired due to Term

• Current Assignee: Peter J. Wilk, Stirbl, Robert C.
• Original Assignee: Peter J. Wilk, Stirbl, Robert C.
• Inventors: Wilk, Peter J., Stirbl, Robert C.
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US08/232,674
• Time in Patent Office: 624 Days
• Field of Search: 128/653.1, 128/653.2, 128/664, 128/665, 128/633, 128/634
• US Class Current: 600/430
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/0507 using microwaves or terahertz waves

Abstract

In a medical diagnostic method a patient is supported in a predetermined position and microwave energy is focused on a predetermined target region in the patient to produce a burst of photoluminescence. Electromagnetic radiation emitted from organic cellular material at the focal point or the microwave radiation is automatically detected. In a subsequent step, a spectral output of the organic cellular material is automatically determined from electromagnetic radiation received from the radiation focal point through the patient during the step of detecting. In addition, a diagnosis of the excited cellular material is automatically implemented based on the results of the spectral analysis.

Claims

1. A medical tissue investigation method comprising the steps of:

generating electromagnetic energy having a predetermined first frequency;

transmitting electromagnetic energy of said first frequency along a predetermined first line extending through a patient;

also generating electromagnetic energy having a predetermined second frequency different from said first frequency;

transmitting electromagnetic energy of said second frequency along a predetermined second line extending through the patient at a predetermined angle relative to said first line, said second line intersecting said first line at one predetermined point inside the patient, said steps of transmitting being performed simultaneously;

automatically detecting electromagnetic radiation emitted from organic cellular material at said predetermined point in response to excitation of said cellular material by electromagnetic energy of said first frequency and electromagnetic energy of said second frequency upon simultaneous irradiation of said predetermined point by electromagnetic energy of said first frequency and electromagnetic energy of said second frequency; and

automatically determining a spectral output of said organic cellular material from electromagnetic radiation received from said predetermined point through the patient during said step of detecting.

2. The method defined in claim 1, further comprising the steps of:

again generating electromagnetic energy having said predetermined first frequency;

again transmitting electromagnetic energy of said first frequency along said predetermined first line extending through the patient;

generating electromagnetic energy having a predetermined third frequency;

transmitting electromagnetic energy of said third frequency along a predetermined third line extending through the patient at a predetermined angle relative to said first line, said third line intersecting said first line at said predetermined point inside the patient, said step of transmitting said electromagnetic energy of third frequency being performed simultaneously with said step of again transmitting electromagnetic energy of said first frequency;

again automatically detecting electromagnetic radiation emitted from said organic cellular material at said predetermined point in response to excitation of said cellular material by electromagnetic energy of said first frequency and electromagnetic energy of said third frequency upon simultaneous irradiation of said predetermined point by electromagnetic energy of said first frequency and electromagnetic energy of said third frequency; and

again automatically determining a spectral output of said organic cellular material from electromagnetic radiation received from said predetermined point through the patient during said step of again automatically detecting.

3. The method defined in claim 1, further comprising the steps of:

directing electromagnetic energy of said second frequency along a predetermined third line extending through the patient at another predetermined angle relative to said first line, said third line intersecting said first line at an additional predetermined point inside the patient, said step of directing being performed simultaneously with said step of transmitting electromagnetic energy of said first frequency;

again automatically detecting electromagnetic radiation emitted from said organic cellular material at said additional predetermined point in response to excitation of said cellular material by electromagnetic energy of said first frequency and electromagnetic energy of said second frequency upon simultaneous irradiation of said additional predetermined point by electromagnetic energy of said first frequency and electromagnetic energy of said second frequency; and

again automatically determining a spectral output of said organic cellular material from electromagnetic radiation received from said predetermined point through the patient during said step of again automatically detecting.

4. The method defined in claim 1 wherein said second frequency has a given phase, a given amplitude and a given polarization, further comprising the steps of:

generating electromagnetic energy having said predetermined second frequency, a selected phase, a selected amplitude, and a selected polarization, at least one of said selected phase, said selected amplitude, and said selected polarization being different from said given phase, said given amplitude and said given polarization, respectively;

transmitting electromagnetic energy of said second frequency with said selected phase, said selected amplitude, and said selected polarization along said second line through the patient simultaneously with a transmission of electromagnetic energy of said first frequency along said first line;

again automatically detecting electromagnetic radiation emitted from organic cellular material at said predetermined point in response to excitation of said cellular material by electromagnetic energy of said first frequency and electromagnetic energy of said second frequency upon simultaneous irradiation of said predetermined point by electromagnetic energy of said first frequency and electromagnetic energy of said second frequency with said selected phase, said selected amplitude, and said selected polarization; and

again automatically determining a spectral output of said organic cellular material from electromagnetic radiation received from said predetermined point through the patient during said step of detecting.

5. The method defined in claim 1 wherein said steps of generating and also generating include the steps of operating a first laser to generate electromagnetic energy of said first frequency and operating a second laser to generate electromagnetic energy of said second frequency, respectively.

6. The method defined in claim 1, further comprising the steps of:

producing electrical signals encoding a first angle identifying said first line and a second angle identifying said second line; and

in response to said electrical signals, computing a location of said predetermined point relative to the patient.

7. The method defined in claim 1 wherein said steps of generating and also generating include the steps of collimating electromagnetic energy of said first frequency and collimating electromagnetic energy of said second frequency, respectively.

8. The method defined in claim 1, further comprising the step of modulating electromagnetic energy of at least one of said first frequency and said second frequency prior to the transmission thereof through the patient.

9. The method defined in claim 8 wherein said step of modulating includes the step of operating a phase locked modulator, further comprising the step of generating an electrical signal in response to said step of detecting, said step of determining including the step of processing said electrical signal, said step of generating including the step of operating a phase locked amplifier.

10. The method defined in claim 1, further comprising the step of varying at least one of said first frequency and said second frequency.

11. The method defined in claim 10 wherein said step of varying is automatically implemented in accordance with a preprogrammed sequence.

12. The method defined in claim 1, further comprising the step of holding a transceiver device by hand, transmission of electromagnetic energy of said first frequency and electromagnetic energy of said second frequency being from said transceiver device, said step of detecting including the step of operating a photoelectric transducer on said transceiver device.

13. The method defined in claim 1 wherein said steps of transmitting include the steps of transmitting electromagnetic energy of said first frequency in a narrow beam along said first line and transmitting electromagnetic energy of said second frequency in a narrow beam along said second line, respectively.

14. The method defined in claim 1, further comprising the steps of focusing electromagnetic energy of said first frequency and focusing electromagnetic energy of said second frequency at said predetermined point.

15. A medical tissue investigation method comprising the steps of:

generating electromagnetic energy characterized by a preselected wavelength, a preselected amplitude, and a preselected polarization;

concentrating said energy towards a predetermined point internal to a patient;

transmitting said energy through the patient to said predetermined point;

automatically detecting electromagnetic radiation emitted from organic cellular material at said predetermined point in response to excitation of said cellular material by said energy upon concentration thereof at said predetermined point; and

automatically determining, from electromagnetic radiation received from said predetermined point through the patient during said step of detecting, a radiation output of said organic cellular material characterized by wavelength, amplitude, and polarization.

16. The method defined in claim 15, further comprising the step of varying at least one of said preselected wavelength, said preselected amplitude, and said preselected polarization.

17. The method defined in claim 16 wherein said step of varying is automatically implemented in accordance with a preprogrammed sequence.

18. The method defined in claim 15, further comprising the step of changing the location of said predetermined point in accordance with a preprogrammed sequence.

19. A medical tissue investigation method comprising the steps of:

generating electromagnetic energy having a predetermined plurality of wavelengths;

modulating at least one of said wavelengths;

transmitting said energy including the modulated wavelength through a patient to a predetermined point internal to the patient;

automatically detecting electromagnetic radiation emitted from organic cellular material at said predetermined point in response to excitation of said cellular material by said energy including the modulated wavelength upon transmission thereof to said predetermined point, said step of detecting including the step of filtering out extraneous background noise in incoming electromagnetic radiation having said one of said wavelengths; and

automatically determining a spectral output of said organic cellular material from electromagnetic radiation received from said predetermined point through the patient during said step of detecting.

20. The method defined in claim 19 wherein said step of modulating includes the step of operating a phase locked modulator, said step of filtering including the step of operating a phase locked amplifier.

21. The method defined in claim 19, further comprising the step of varying said one of said wavelengths.

22. The method defined in claim 21 wherein said step of varying said one of said wavelengths is automatically implemented in accordance with a preprogrammed sequence.

23. The method defined in claim 19, further comprising the step of automatically changing the location of said predetermined point pursuant to a predetermined sequence.

24. The method defined in claim 19 wherein said step of changing is automatically implemented by transmitting said energy to another point internal to the patient and different from said predetermined point.

25. A medical tissue investigation method comprising the steps of:

generating electromagnetic energy having a predetermined plurality of wavelengths;

transmitting said energy through a patient to a predetermined point internal to the patient;

concentrating said energy at said predetermined point;

automatically determining the location of said predetermined point relative to the patient;

automatically detecting electromagnetic radiation emitted from organic cellular material at said predetermined point in response to excitation of said cellular material by said energy upon concentrating thereof at said predetermined point;

automatically determining a spectral output of said organic cellular material from electromagnetic radiation received from said predetermined point through the patient during said step of detecting; and

correlating the determined spectral output of said organic cellular material with the location of said predetermined point relative to the patient.

26. The method defined in claim 25 wherein said step of determining the location of said predetermined point includes the step of operating a wireless imaging device.

27. The method defined in claim 25 wherein said step of determining the location of said predetermined point includes the step of automatically determining a direction of transmission of said energy through the patient.

28. The method defined in claim 25, further comprising the step of varying said wavelengths.

29. A medical tissue investigation system comprising:

first generating means for generating electromagnetic energy having a predetermined first frequency;

first directional transmission means for transmitting electromagnetic energy of said first frequency along a predetermined first line extending through a patient;

second generating means for generating electromagnetic energy having a predetermined second frequency different from said first frequency;

second directional transmission means for transmitting electromagnetic energy of said second frequency along a predetermined second line extending through the patient at a predetermined angle relative to said first line, said second line intersecting said first line at one predetermined point inside the patient;

detection means for automatically detecting electromagnetic radiation emitted from organic cellular material at said predetermined point in response to excitation of said cellular material by electromagnetic energy of said first frequency and electromagnetic energy of said second frequency upon simultaneous irradiation of said predetermined point by electromagnetic energy of said first frequency and electromagnetic energy of said second frequency; and

computing means operatively connected to said detection means for automatically determining a spectral output of said organic cellular material from electromagnetic radiation received from said predetermined point through the patient,

said computing means being operatively connected to at least one of said first generating means and said second generating means for controlling said one of said first generating means and said second generating means to change a respective one of said first frequency and said second frequency,

said computing means being operatively connected to at least one of said first directional transmission means and said second directional transmission means for controlling said one of said first directional transmission means and said second direction transmission means to change a respective one of said first line and said second line.

30. The system defined in claim 29 wherein at least one of said first directional transmission means and said second directional transmission means includes means for changing said angle by changing a direction of a respective one of said first line and said second line.

31. The system defined in claim 29 wherein said second generating means includes means for changing at least one of an amplitude, a phase and a polarization of electromagnetic energy of said second frequency.

32. The system defined in claim 29 wherein at least one of said first generating means and said second generating means includes a laser for generating electromagnetic energy of a respective one of said first frequency and said second frequency.

33. The system defined in claim 29, further comprising signal generating means operatively connected to said first directional transmission means and said second directional transmission means for producing electrical signals encoding a first angle identifying said first line and a second angle identifying said second line, said computing means being operatively connected to said signal generating means for computing a location of said predetermined point relative to the patient in response to said electrical signals.

34. The system defined in claim 29 wherein at least one of said first generator means and said second generating means includes means for collimating electromagnetic energy of a respective one of said first frequency and said second frequency.

35. The system defined in claim 29, further comprising modulator means for modulating electromagnetic energy of at least one of said first frequency and said second frequency prior to the transmission thereof through the patient.

36. The system defined in claim 35 wherein said modulator means includes a phase locked modulator, said detection means including a phase locked amplifier for generating an electrical signal encoding incoming detected electromagnetic energy.

37. The system defined in claim 29, further comprising a portable transceiver device, said first direction transmission means and said second directional transmission means being disposed on said transceiver device, said detection means including a photoelectric transducer on said transceiver device.

38. A medical tissue investigation system comprising:

generating means for generating electromagnetic energy characterized by a preselected wavelength, a preselected amplitude, and a preselected polarization;

transmission means for transmitting said energy through a patient to a predetermined point internal to the patient;

detection means for automatically detecting electromagnetic radiation emitted from organic cellular material at said predetermined point in response to excitation of said cellular material by said energy upon concentration thereof at said predetermined point; and

computing means operatively connected to said detection means for automatically determining, from electromagnetic radiation received from said predetermined point through the patient, a radiation output of said organic cellular material characterized by wavelength, amplitude, and polarization,

said computing means being operatively connected to said generating means for controlling said generating means to change at least one of said preselected wavelength, said preselected amplitude, and said preselected polarization.

39. The system defined in claim 38 wherein said computing means includes means for automatically varying said at least one of said preselected wavelength, said preselected amplitude, and said preselected polarization in accordance with a preprogrammed sequence.

40. A medical tissue investigation system comprising:

generating means for generating electromagnetic energy having a predetermined plurality of wavelengths;

modulator means operatively connected to said generating means for modulating at least one of said wavelengths;

transmission means for transmitting said energy including the modulated wavelength through a patient to a predetermined point internal to the patient;

detection means for automatically detecting electromagnetic radiation emitted from organic cellular material at said predetermined point in response to excitation of said cellular material by said energy including the modulated wavelength upon transmission thereof to said predetermined point, said detection means including filtering means for filtering out extraneous background noise in incoming electromagnetic radiation having said one of said wavelengths; and

computing means operatively connected to said detection means for automatically determining a spectral output of said organic cellular material from electromagnetic radiation received from said predetermined point through the patient.

41. The system defined in claim 40, wherein said modulator means includes a phase locked modulator, said detection means including a phase locked amplifier.

42. The system defined in claim 40, further comprising means for varying said one of said wavelengths.