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Sustained release bactericidal cannula

  • US 5,482,740 A
  • Filed: 11/08/1993
  • Issued: 01/09/1996
  • Est. Priority Date: 01/10/1990
  • Status: Expired due to Term
First Claim
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1. A method for making a sustained release bactericidal cannula, the cannula being made from a tube, the tube having an inner surface, defining an inner lumen passing through the tube, and an uncured silicone rubber outer surface, said method comprising the steps of:

  • (a) providing an antibacterial agent containing mixture including uncured silicone rubber and particles of a solid antibacterial agent, wherein the antibacterial agent is a nitrofuran compound having a solubility in water of 0.2% by weight or less and wherein the mixture has a different composition from that of the uncured silicone rubber outer surface;

    (b) coating at least a portion of the outer surface of the tube with the antibacterial agent containing mixture to form an uncured nitrofuran containing silicone rubber outer layer; and

    (c) curing the silicone rubber of both the uncured silicone rubber outer surface and the uncured nitrofuran containing silicone rubber outer layer to form a cured antibacterial agent containing silicone rubber outer layer bonded to the silicone rubber outer surface;

    wherein the step of providing includes providing an antibacterial agent containing mixture containing a sufficient amount of the nitrofuran compound that the cured antibacterial agent containing silicone rubber outer layer contains about 10 to about 60 percent by weight of the nitrofuran compound.

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