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Certain N(4-benzoyl-2-phenyl)-3- trifluoro-2-hydroxy-propanamide derivatives

  • US 5,482,969 A
  • Filed: 03/11/1994
  • Issued: 01/09/1996
  • Est. Priority Date: 03/15/1993
  • Status: Expired due to Term
First Claim
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1. A compound formula Ib:

  • whereinAr is phenyl, optionally substituted with a substituent selected from (1-4C)alkyl;

    Y is carbonyl;

    A-B is --NHC(═

    O)--;

    R9 is selected from the group consisting of (1-4C)haloalkyl, (1-4C)alkoxy, (2-4C)alkenyloxy, cyano, nitro, halo, trifluoromethyl, trifluoromethylthio, trifluoromethoxy, and hydroxy;

    R10 is hydrogen;

    R11 is selected from hydrogen, halo, methyl, hydroxy, methoxy, and cyano; and

    R2 and R3 are independently (1-3C)alkyl substituted by from 0 to 2k+1 atoms selected from fluoro and chloro wherein k is the number of carbon atoms in the said (1-3C)alkyl, provided that R2 and R3 are not both methyl;

    orR2 and R3, together with the carbon atom to which they are attached, form a 3-5 membered cycloalkyl ring optionally substituted by from 0 to 2m-2 fluorine atoms wherein m is the number of carbon atoms in said ring;

    or a pharmaceutically acceptable salt of said compound;

    provided said compound is not N-(4-Benzoyl-2,6-dimethylphenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide.

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