Therapeutic compositions and methods
First Claim
1. A composition comprising:
- (i) granules comprising a biologically active material in association with a week base, the granules being partially coated with a delayed release material substantially impermeable at pH below about 6.0 and soluble in intestinal joice;
(ii) an acidifying agent having a pH between about 1.5 to about 6 when in solution; and
(iii) a gel forming agent.
1 Assignment
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Accused Products
Abstract
Compositions comprising (i) granules comprising a biologically active material in association with a weak base and partially coated with a delayed release material soluble in intestinal juice, (ii) an acidifying agent having a pH between 1.5 to 6, and (iii) a gel forming agent are described. There is also described a composition comprising an acidic gel having a pH between 1.5 to 6 and containing microgranules comprising a biologically active material in association with a weak base and partially coated with a delayed release material soluble in intestinal juice. The compositions may be used in the treatment of diseases associated with intestinal pathogens in animals. Where the biologically active material is a protease, receptor/adhesion sites in the intestines for pathogens may be proteolysed so as to prevent pathogen binding to intestinal surfaces.
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Citations
38 Claims
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1. A composition comprising:
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(i) granules comprising a biologically active material in association with a week base, the granules being partially coated with a delayed release material substantially impermeable at pH below about 6.0 and soluble in intestinal joice; (ii) an acidifying agent having a pH between about 1.5 to about 6 when in solution; and (iii) a gel forming agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 18, 19, 20, 22, 23, 24, 25, 26, 27, 28, 33, 34, 35, 36, 37, 38)
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11. A composition comprising:
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an acidic gel having a pH between about 1.5 to about 6; and microgranules comprising a biologically active material in association with a weak base, the microgranules being partially coated with a delayed release material substantially impermeable at pH below about 6.0 and soluble in intestinal juice. - View Dependent Claims (12, 13, 14, 15, 16, 17, 21, 31)
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- 29. A method for the treatment of diarrhoea in an animal comprising administering to the animal an acidic gel having a pH between about 1.5 to about 6, said gel containing microgranules comprising a proteolytic enzyme in association with a weak base, the microgranules being partially coated with a delayed release material soluble in intestinal juice but substantially impermeable at a pH below about 6.0.
Specification