Calcium-modified oxidized cellulose hemostat
First Claim
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1. A bioabsorbable surgical hemostat comprising a neutralized oxidized cellulose fabric comprising between about 0.5% and about 4.0% calcium.
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Abstract
A calcium-modified oxidized cellulose hemostat provides faster hemostasis than does either unmodified or sodium- or potassium-modified oxidized cellulose. The percentage by weight of calcium in the modified oxidized cellulose must be in a range between about 0.5 and about 4, in order to enhance hemostasis, while not interfering excessively with bioabsorbability. In a second embodiment, an oxidized cellulose hemostat is modified with both calcium and either sodium or potassium. The second embodiment may be used to deliver acid-sensitive materials.
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17 Claims
- 1. A bioabsorbable surgical hemostat comprising a neutralized oxidized cellulose fabric comprising between about 0.5% and about 4.0% calcium.
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5. A process for preparing a bioabsorbable surgical hemostat comprising the steps of:
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(a) contacting an oxidized cellulose material that contains a predetermined concentration of carboxylic acid with a sufficient quantity of a chloride-free solution of a calcium salt of a weak acid to neutralize about 5.5% to about 45% of the carboxylic acid and provide a calcium content in the fabric of between about 0.5% and about 4.0%; and (b) washing the material to remove excess salt. - View Dependent Claims (12, 13, 14)
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6. A process for preparing a bioabsorbable surgical hemostat comprising the steps of:
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(a) contacting an oxidized cellulose material that contains a predetermined concentration of carboxylic acid with a sufficient quantity of a chloride-free solution of a calcium salt of a weak acid and a quantity of a sodium or potassium salt of a weak acid to neutralize about 50% to about 80% of the carboxylic acid, with the calcium neutralizing about 5.5% to about 45% of the acid the sodium or potassium salt neutralizing the balance, and providing a calcium content in the fabric of between about 0.5% and about 4.0%; and (b) washing the material to remove excess salt. - View Dependent Claims (7, 15, 16, 17)
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Specification