Surgical adhesive sheet, surgical instruments and methods of using the same

• US 5,486,547 A
• Filed: 11/03/1994
• Issued: 01/23/1996
• Est. Priority Date: 03/23/1989
• Status: Expired due to Term

• Current Assignee: Sanyo Chemical Industries Limited
• Original Assignee: Sanyo Chemical Industries Limited
• Inventors: Tani, Tohru, Itoh, Tetsuo, Matsuda, Takehisa
• Primary Examiner(s): Michl, Paul R.
• Assistant Examiner(s): Merriam, Andrew E. C.
• Application Number:
  US08/335,341
• Time in Patent Office: 446 Days
• Field of Search: 523/111, 523/118, 528/905, 428/424.6, 428/425.1, 428/425.5, 428/423.3, 602/52, 602/54, 424/443
• US Class Current: 523/111
• CPC Class Codes: A61B 17/00 Surgical instruments, devices or methods, e.g. tourniquets A61B18/00 takes precedence; contraceptive devices, pessaries, or applicators therefor A61F6/00; eye surgery A61F9/007; ear surgery A61F11/00
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 17/11 for performing anastomosis; Buttons for anastomosis
• CPC Class Codes: A61B 17/1114 of the digestive tract, e.g. bowels or oesophagus
• CPC Class Codes: A61B 2017/1107 for blood vessels
• CPC Class Codes: A61B 2017/1125 Forceps, specially adapted for performing or assisting anastomosis
• CPC Class Codes: A61F 13/01012 being made of natural material, e.g. cellulose-, protein-, collagen-based
• CPC Class Codes: A61F 13/0209 comprising superabsorbent material
• CPC Class Codes: A61F 13/0226 characterised by the support layer
• CPC Class Codes: A61F 13/023 wound covering film layers without a fluid retention layer
• CPC Class Codes: A61F 13/0273 Adhesive bandages for winding around limb, trunk or head, e.g. cohesive
• CPC Class Codes: A61F 13/15252 compostable or biodegradable
• CPC Class Codes: A61F 13/551 Packaging before or after use general packaging of absorbent pads B65D85/00
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61F 2013/00463 haemostatic
• CPC Class Codes: A61F 2013/00472 with chemical means
• CPC Class Codes: A61F 2013/00489 for bracing or strapping
• CPC Class Codes: A61F 2013/00519 for treating burn
• CPC Class Codes: A61F 2013/00604 Multilayer
• CPC Class Codes: A61F 2013/00659 : polymeric base
• CPC Class Codes: A61F 2013/00719 : adhesives for use on wounds
• CPC Class Codes: A61F 2013/0091 : with disinfecting or anaesthetics means, e.g. anti-mycrobic
• CPC Class Codes: A61F 2013/00927 : with biological activity, e.g. enzymes for debriding wounds or others, collagen or growth factors
• CPC Class Codes: A61L 31/10 : Macromolecular materials
• CPC Class Codes: C08L 75/04 : Polyurethanes
• CPC Class Codes: Y10S 528/905 : Polymer prepared from isocyanate reactant has adhesive property
• CPC Class Codes: Y10T 428/31554 : Next to second layer of polyamidoester
• CPC Class Codes: Y10T 428/31562 : Next to polyamide [nylon, etc.]
• CPC Class Codes: Y10T 428/31576 : Ester monomer type [polyvinylacetate, etc.]
• CPC Class Codes: Y10T 428/3158 : Halide monomer type [polyvinyl chloride, etc.]
• CPC Class Codes: Y10T 428/31587 : Hydrocarbon polymer [polyethylene, polybutadiene, etc.]
• CPC Class Codes: Y10T 428/31591 : Next to cellulosic
• CPC Class Codes: Y10T 428/31598 : Next to silicon-containing [silicone, cement, etc.] layer

Abstract

A sheet material, coated with a surgical adhesive comprising an NCO-terminated urethane prepolymer, is used for bonding of tissues, with improved handleability.

Surgical instruments, comprising a non-adherent material towards an NCO-terminated urethane prepolymer, are used for application of surgical adhesive. Such instruments, comprising a rod tapered so that the tip can be partly inserted into blood vessel, are suitable for anastomosis of blood vessel.

Claims

1. A surgical adhesive sheet, comprising

a sheet material comprising at least one polymer selected from the group consisting of polyurethane resins, silicone resins and fluorine-containing resins, coated with

a surgical adhesive comprising an NCO-terminated urethane prepolymer having a free isocyanate group content of 2-10% by weight, wherein said sheet is anhydrous or contains water in an amount insufficient to crosslink the prepolymer.

2. The surgical adhesive sheet of claim 1, said sheet material being a film capable of transferring said surgical adhesive to tissue.

4. The sheet of claim 1, wherein said prepolymer is derived from at least one organic polyisocyanate and a polyol component comprising at least one hydrophilic polyether polyol having an oxyethylene content of at least 30% by weight of the polyol.

5. The sheet of claim 4, wherein said polyol component has an equivalent weight (average) of 100-5,000 and a functionality (average) of 2-8.

6. The sheet of claim 4, wherein said polyisocyanate is at least one selected from the group consisting of aromatic polyisocyanates containing 6-20 carbon atoms, aliphatic polyisocyanates containing 2-18 carbon atoms, allcyclic polyisocyanates containing 4-15 carbon atoms, araliphatic polyisocyanates containing 8-15 carbon atoms, except carbon atoms in NCO groups, and modified polyisocyanates of these polyisocyanates containing one or more of urethane, carbodiimide, allophanate, urea, biuret, urethdione, urethimine, isocyanurate and oxazolidone groups.

7. The sheet of claim 4, wherein said polyisocyanate comprises a fluorine-containing polyisocyanate.

12. The sheet of claim 5, wherein the maximum average molecular weight of the polyol component is about 4,000.

3. A surgical adhesive sheet, comprising

a biodegradable sheet material comprising at least one polymer selected from the group consisting of polyamino acids, polyamino acid copolymers, oxidized cellulose, chitin, collagen, polylactic acids, polyglycolic acids, polyhydroxybutyric acids, and copolymers of lactic acid and glycolic acid, coated with

a surgical adhesive comprising an NCO-terminated urethane prepolymer having a free isocyanate group content of 2-10% by weight, wherein said sheet is anhydrous or contains water in an amount insufficient to crosslink the prepolymer.

8. The sheet of claim 3, wherein said prepolymer is derived from at least one organic polyisocyanate and a polyol component comprising at least one hydrophilic polyether polyol having an oxyethylene content of at least 30% by weight of the polyol.

9. The sheet of claim 8, wherein said polyol component has an equivalent weight (average) of 100-5,000 and a functionality (average) of 2-8.

10. The sheet of claim 8, wherein said polyisocyanate is at least one selected from the group consisting of aromatic polyisocyanates containing 6-20 carbon atoms, aliphatic polyisocyanates containing 2-18 carbon atoms, alicyclic polyisocyanates containing 4-15 carbon atoms, araliphatic polyisocyanates containing 8-15 carbon atoms, except carbon atoms in NCO groups, and modified polyisocyanates of these polyisocyanates containing one or more of urethane, carbodiimide, allophanate, urea, biuret, urethdione, urethimine, isocyanurate and oxazolidone groups.

11. The sheet of claim 8, wherein said polyisocyanate comprises a fluorine-containing polyisocyanate.

13. The sheet of claim 9, wherein the maximum average molecular weight of the polyol component is about 4,000.